(S)-tert-butyl 1-(1-benzyl-1H-indol-3-yl)-3-hydroxypropan-2-ylcarbamate

Base Information

Chemical Name:(S)-tert-butyl 1-(1-benzyl-1H-indol-3-yl)-3-hydroxypropan-2-ylcarbamate
CAS No.:1163710-08-4
Molecular Formula:C₂₃H₂₈N₂O₃
Molecular Weight:380.487
Hs Code.:

Synonyms:(S)-tert-butyl 1-(1-benzyl-1H-indol-3-yl)-3-hydroxypropan-2-ylcarbamate

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Chemical Property of (S)-tert-butyl 1-(1-benzyl-1H-indol-3-yl)-3-hydroxypropan-2-ylcarbamate

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Technology Process of (S)-tert-butyl 1-(1-benzyl-1H-indol-3-yl)-3-hydroxypropan-2-ylcarbamate

There total 5 articles about (S)-tert-butyl 1-(1-benzyl-1H-indol-3-yl)-3-hydroxypropan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1163710-07-3
benzyl (S)-3-(1-benzyl-1H-indol-3-yl)-2-[(tert-butoxycarbonyl)amino]propanoate

: 1163710-08-4
(S)-tert-butyl 1-(1-benzyl-1H-indol-3-yl)-3-hydroxypropan-2-ylcarbamate

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/jo9007223

Reference yield:

: N¹-benzyl-N-(tert-butoxycarbonyl)-L-tryptophan

: 1163710-08-4
(S)-tert-butyl 1-(1-benzyl-1H-indol-3-yl)-3-hydroxypropan-2-ylcarbamate

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1002/adsc.202101401

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1163710-08-4
(S)-tert-butyl 1-(1-benzyl-1H-indol-3-yl)-3-hydroxypropan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / tetrahydrofuran; water / 0.33 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

2.2: 0 - 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

With lithium aluminium tetrahydride; sodium hydride; sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/adsc.202101401