(phenylacetyl)-2(S)-malyl-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-(methyloctanoyl)-2(S)-methylbutylamine

Base Information

Chemical Name:(phenylacetyl)-2(S)-malyl-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-(methyloctanoyl)-2(S)-methylbutylamine
CAS No.:124344-03-2
Molecular Formula:C₂₉H₄₆N₂O₇
Molecular Weight:534.693
Hs Code.:

Synonyms:(phenylacetyl)-2(S)-malyl-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-(methyloctanoyl)-2(S)-methylbutylamine

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Chemical Property of (phenylacetyl)-2(S)-malyl-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-(methyloctanoyl)-2(S)-methylbutylamine

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Technology Process of (phenylacetyl)-2(S)-malyl-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-(methyloctanoyl)-2(S)-methylbutylamine

There total 7 articles about (phenylacetyl)-2(S)-malyl-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-(methyloctanoyl)-2(S)-methylbutylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 126082-60-8
(phenylacetyl)-1-benzyl-2(S)-malyl-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-(methyloctanoyl)-2(S)-methylbutylamine

: 124344-03-2
(phenylacetyl)-2(S)-malyl-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-(methyloctanoyl)-2(S)-methylbutylamine

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 2h; under 2585.7 Torr;
DOI:10.1021/jm00167a009

Reference yield:

: 34985-37-0
(S)-2-methylbutylamine

: 124344-03-2
(phenylacetyl)-2(S)-malyl-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-(methyloctanoyl)-2(S)-methylbutylamine

Guidance literature:: Multi-step reaction with 6 steps

1: 97 percent / diisopropylethylamine, diethylphosphoryl cyanide (DEPC) / 6 h / Ambient temperature

2: 173 mg / trifluoroacetic acid (TFA) / CH₂Cl₂ / 0.75 h / Ambient temperature

3: 49 percent / diisopropylethylamine, diethylphosphoryl cyanide (DEPC) / CH₂Cl₂ / Ambient temperature

4: 73 percent / 4-(dimethylamino)pyridine (DMAP) / CH₂Cl₂ / Ambient temperature

5: 50 mg / trifluoroacetic acid (TFA) / CH₂Cl₂ / 1 h / Ambient temperature

6: 66 percent / H₂ / 5percent Pd/C / methanol / 2 h / 2585.7 Torr

With dmap; diethylphosphoryl cyanide; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jm00167a009

Reference yield:

: 123471-20-5
(2S,4S,5S)-5-Amino-4-(tert-butyl-dimethyl-silanyloxy)-2-isopropyl-7-methyl-octanoic acid ((S)-2-methyl-butyl)-amide

: 124344-03-2
(phenylacetyl)-2(S)-malyl-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-(methyloctanoyl)-2(S)-methylbutylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 49 percent / diisopropylethylamine, diethylphosphoryl cyanide (DEPC) / CH₂Cl₂ / Ambient temperature

2: 73 percent / 4-(dimethylamino)pyridine (DMAP) / CH₂Cl₂ / Ambient temperature

3: 50 mg / trifluoroacetic acid (TFA) / CH₂Cl₂ / 1 h / Ambient temperature

4: 66 percent / H₂ / 5percent Pd/C / methanol / 2 h / 2585.7 Torr

With dmap; diethylphosphoryl cyanide; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jm00167a009