2,6-dichloro-9-(3,5,6-tri-O-benzoyl-2-deoxy-2-fluoro-4-C-hydroxymethyl-D-arabinofuranosyl)-9H-purine

Base Information

Chemical Name:2,6-dichloro-9-(3,5,6-tri-O-benzoyl-2-deoxy-2-fluoro-4-C-hydroxymethyl-D-arabinofuranosyl)-9H-purine
CAS No.:379216-02-1
Molecular Formula:C₃₂H₂₃Cl₂FN₄O₇
Molecular Weight:665.462
Hs Code.:

Synonyms:2,6-dichloro-9-(3,5,6-tri-O-benzoyl-2-deoxy-2-fluoro-4-C-hydroxymethyl-D-arabinofuranosyl)-9H-purine

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Chemical Property of 2,6-dichloro-9-(3,5,6-tri-O-benzoyl-2-deoxy-2-fluoro-4-C-hydroxymethyl-D-arabinofuranosyl)-9H-purine

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Technology Process of 2,6-dichloro-9-(3,5,6-tri-O-benzoyl-2-deoxy-2-fluoro-4-C-hydroxymethyl-D-arabinofuranosyl)-9H-purine

There total 11 articles about 2,6-dichloro-9-(3,5,6-tri-O-benzoyl-2-deoxy-2-fluoro-4-C-hydroxymethyl-D-arabinofuranosyl)-9H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 5451-40-1
2,6 dichloropurine

: 1-O-acetyl-3,5,6-tri-O-benzoyl-2-deoxy-2-fluoro-4-C-hydroxymethyl-D-arabinofuranose

: 379216-02-1
2,6-dichloro-9-(3,5,6-tri-O-benzoyl-2-deoxy-2-fluoro-4-C-hydroxymethyl-D-arabinofuranosyl)-9H-purine

Guidance literature:: With sodium hydride; In acetonitrile; at 20 ℃; for 18h;
DOI:10.1081/NCN-100002421

Reference yield:

: 97614-44-3
2-deoxy-2-fluoro-3,5-di-O-benzoyl-α-D-arabinofuranosyl bromide

: 379216-02-1
2,6-dichloro-9-(3,5,6-tri-O-benzoyl-2-deoxy-2-fluoro-4-C-hydroxymethyl-D-arabinofuranosyl)-9H-purine

Guidance literature:: Multi-step reaction with 11 steps

1: methanol / 0 °C

2: NaOMe / methanol / 20 °C

3: KOH / tetrahydrofuran

4: H₂; pyridine / Pd/C / methanol; acetic acid; pyridine / 2585.74 Torr

5: pyridinium chlorochromate; molecular sieves 4 Angstroem / CH₂Cl₂

6: NaOH / tetrahydrofuran; H₂O

7: H₂ / Pd/C / methanol; acetic acid / 2585.74 Torr

8: pyridine

9: TFA / H₂O / 55 °C

10: pyridine

11: 82 percent / NaH / acetonitrile / 18 h / 20 °C

With pyridine; potassium hydroxide; sodium hydroxide; 4 A molecular sieve; hydrogen; sodium methylate; sodium hydride; pyridinium chlorochromate; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; dichloromethane; water; acetic acid; acetonitrile;
DOI:10.1081/NCN-100002421

Reference yield:

: 136315-44-1
2-Deoxy-2-fluoro-1-O-methyl-β-D-arabinofuranose

: 379216-02-1
2,6-dichloro-9-(3,5,6-tri-O-benzoyl-2-deoxy-2-fluoro-4-C-hydroxymethyl-D-arabinofuranosyl)-9H-purine

Guidance literature:: Multi-step reaction with 9 steps

1: KOH / tetrahydrofuran

2: H₂; pyridine / Pd/C / methanol; acetic acid; pyridine / 2585.74 Torr

3: pyridinium chlorochromate; molecular sieves 4 Angstroem / CH₂Cl₂

4: NaOH / tetrahydrofuran; H₂O

5: H₂ / Pd/C / methanol; acetic acid / 2585.74 Torr

6: pyridine

7: TFA / H₂O / 55 °C

8: pyridine

9: 82 percent / NaH / acetonitrile / 18 h / 20 °C

With pyridine; potassium hydroxide; sodium hydroxide; 4 A molecular sieve; hydrogen; sodium hydride; pyridinium chlorochromate; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; dichloromethane; water; acetic acid; acetonitrile;
DOI:10.1081/NCN-100002421