4-Methylpyridine-2-sulfonamide

Base Information

• Chemical Name: 4-Methylpyridine-2-sulfonamide
• CAS No.: 65938-78-5
• Molecular Formula: C6H8N2O2S
• Molecular Weight: 172.208
• Hs Code.: 2935009090
• DSSTox Substance ID: DTXSID50485444
• Wikidata: Q82324637
• Mol file: 65938-78-5.mol

Synonyms:4-methylpyridine-2-sulfonamide;65938-78-5;2-Pyridinesulfonamide,4-methyl-(9CI);SCHEMBL3675739;DTXSID50485444;GS1187;AKOS008148431;AM101097;CS-0529637;EN300-76860;F84392;A835283;Z854066780

Chemical Property of 4-Methylpyridine-2-sulfonamide

Chemical Property:

• Boiling Point: 381.598 °C at 760 mmHg
• Flash Point: 184.584 °C
• PSA: 81.43000
• Density: 1.347 g/cm³
• LogP: 1.81850
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 172.03064868
• Heavy Atom Count: 11
• Complexity: 219

Purity/Quality:

99% ^*data from raw suppliers

4-methylpyridine-2-sulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=NC=C1)S(=O)(=O)N

Technology Process of 4-Methylpyridine-2-sulfonamide

There total 4 articles about 4-Methylpyridine-2-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

6-bromo-4-methylpyridine-2-sulfonyl chloride → 4-methyl-pyridine-2-sulfonic acid amide (65938-78-5)

Guidance literature:

With ammonium; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

Reference yield:

2-(benzylsulfanyl)-6-bromo-4-methylpyridine → 4-methyl-pyridine-2-sulfonic acid amide (65938-78-5)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; N-chloro-succinimide / water / 1 h / 20 °C

2: ammonium / tetrahydrofuran / 1 h / 0 - 20 °C

With N-chloro-succinimide; acetic acid; In tetrahydrofuran; water;

Reference yield:

2,6-Dibromo-4-methylpyridine (73112-16-0) → 4-methyl-pyridine-2-sulfonic acid amide (65938-78-5)

Guidance literature:

Multi-step reaction with 3 steps

1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

2: acetic acid; N-chloro-succinimide / water / 1 h / 20 °C

3: ammonium / tetrahydrofuran / 1 h / 0 - 20 °C

With N-chloro-succinimide; caesium carbonate; acetic acid; In tetrahydrofuran; water; N,N-dimethyl-formamide;

upstream raw materials:

4-methylpyridine-2-thiol

2,6-Dibromo-4-methylpyridine

Downstream raw materials:

2,4-dimethylpyridine N-oxide