(R)-1-{3-[4-(4-methoxyphenylamino)-2-oxopyridin-1(2H)-yl]propanamido}-3-methylbutylboronic acid

Base Information

Chemical Name:(R)-1-{3-[4-(4-methoxyphenylamino)-2-oxopyridin-1(2H)-yl]propanamido}-3-methylbutylboronic acid
CAS No.:1624283-43-7
Molecular Formula:C₂₀H₂₈BN₃O₅
Molecular Weight:401.27
Hs Code.:

Synonyms:(R)-1-{3-[4-(4-methoxyphenylamino)-2-oxopyridin-1(2H)-yl]propanamido}-3-methylbutylboronic acid

Suppliers and Price of (R)-1-{3-[4-(4-methoxyphenylamino)-2-oxopyridin-1(2H)-yl]propanamido}-3-methylbutylboronic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-1-{3-[4-(4-methoxyphenylamino)-2-oxopyridin-1(2H)-yl]propanamido}-3-methylbutylboronic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (R)-1-{3-[4-(4-methoxyphenylamino)-2-oxopyridin-1(2H)-yl]propanamido}-3-methylbutylboronic acid

There total 6 articles about (R)-1-{3-[4-(4-methoxyphenylamino)-2-oxopyridin-1(2H)-yl]propanamido}-3-methylbutylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1624283-97-1
(R)-1-{3-[4-(4-methoxyphenylamino)-2-oxopyridin-1(2H)-yl]propanamido}-3-methylbutylboronic acid pinanediol ester

: 1624283-43-7
(R)-1-{3-[4-(4-methoxyphenylamino)-2-oxopyridin-1(2H)-yl]propanamido}-3-methylbutylboronic acid

Guidance literature:: With hydrogenchloride; Dihydroxy-isobutyl-boran; In methanol; hexane; water; at 20 ℃; for 18h;
DOI:10.1002/cmdc.201402075

Reference yield:

: 1624283-70-0
methyl 3-[4-(4-methoxyphenylamino)-2-oxopyridin-1(2H)-yl]propanoate

: 1624283-43-7
(R)-1-{3-[4-(4-methoxyphenylamino)-2-oxopyridin-1(2H)-yl]propanamido}-3-methylbutylboronic acid

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide / methanol; water / 4 h / 0 - 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / -15 - 20 °C

3: hydrogenchloride; Dihydroxy-isobutyl-boran / methanol; hexane; water / 18 h / 20 °C

With hydrogenchloride; Dihydroxy-isobutyl-boran; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In methanol; hexane; dichloromethane; water;
DOI:10.1002/cmdc.201402075

Reference yield:

: 1624283-58-4
2-(Benzyloxy)-N-(4-methoxyphenyl)pyridin-4-amine

: 1624283-43-7
(R)-1-{3-[4-(4-methoxyphenylamino)-2-oxopyridin-1(2H)-yl]propanamido}-3-methylbutylboronic acid

Guidance literature:: Multi-step reaction with 5 steps

1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 2 h / 20 °C

2: sodium hydride / N,N-dimethyl-formamide / 13 h / 0 - 20 °C / Reflux

3: lithium hydroxide / methanol; water / 4 h / 0 - 20 °C

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / -15 - 20 °C

5: hydrogenchloride; Dihydroxy-isobutyl-boran / methanol; hexane; water / 18 h / 20 °C

With hydrogenchloride; Dihydroxy-isobutyl-boran; palladium 10% on activated carbon; hydrogen; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In methanol; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201402075