Ethyl 1-(3-chlorophenyl)-5-(3-cyano-5-fluorophenyl)-1H-pyrazole-3-carboxylate

Base Information

Chemical Name:Ethyl 1-(3-chlorophenyl)-5-(3-cyano-5-fluorophenyl)-1H-pyrazole-3-carboxylate
CAS No.:1187919-32-9
Molecular Formula:C₁₉H₁₃ClFN₃O₂
Molecular Weight:369.783
Hs Code.:

Synonyms:Ethyl 1-(3-chlorophenyl)-5-(3-cyano-5-fluorophenyl)-1H-pyrazole-3-carboxylate

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Chemical Property of Ethyl 1-(3-chlorophenyl)-5-(3-cyano-5-fluorophenyl)-1H-pyrazole-3-carboxylate

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Technology Process of Ethyl 1-(3-chlorophenyl)-5-(3-cyano-5-fluorophenyl)-1H-pyrazole-3-carboxylate

There total 3 articles about Ethyl 1-(3-chlorophenyl)-5-(3-cyano-5-fluorophenyl)-1H-pyrazole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1187919-28-3
Ethyl 4-(3-cyano-5-fluorophenyl)-2,4-dioxobutyrate

: 2312-23-4
m-chlorophenylhydrazine hydrochloride

: 1187919-32-9
Ethyl 1-(3-chlorophenyl)-5-(3-cyano-5-fluorophenyl)-1H-pyrazole-3-carboxylate

Guidance literature:: Ethyl 4-(3-cyano-5-fluorophenyl)-2,4-dioxobutyrate; m-chlorophenylhydrazine hydrochloride; In ethanol; at 20 ℃; for 2h;

With acetic acid; In ethanol; at 20 - 60 ℃; for 3h;

Reference yield:

: 179898-34-1
3-bromo-5-fluorobenzonitrile

: 1187919-32-9
Ethyl 1-(3-chlorophenyl)-5-(3-cyano-5-fluorophenyl)-1H-pyrazole-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / Inert atmosphere; Reflux

1.2: 2 h / 20 °C

2.1: lithium hexamethyldisilazane / hexane; diethyl ether / 1 h / -78 °C / Inert atmosphere

2.2: 20 °C

3.1: ethanol / 2 h / 20 °C

3.2: 3 h / 20 - 60 °C

With 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; lithium hexamethyldisilazane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In diethyl ether; ethanol; hexane; toluene;

Reference yield:

: 105515-21-7
3-acetyl-5-fluorobenzenecarbonitrile

: 1187919-32-9
Ethyl 1-(3-chlorophenyl)-5-(3-cyano-5-fluorophenyl)-1H-pyrazole-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / hexane; diethyl ether / 1 h / -78 °C / Inert atmosphere

1.2: 20 °C

2.1: ethanol / 2 h / 20 °C

2.2: 3 h / 20 - 60 °C

With lithium hexamethyldisilazane; In diethyl ether; ethanol; hexane;