(2-{5-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-phenyl]-[1,3,4]oxadiazol-2-ylamino}-ethyl)-methyl-carbamic acid tert-butyl ester

Base Information

• Chemical Name: (2-{5-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-phenyl]-[1,3,4]oxadiazol-2-ylamino}-ethyl)-methyl-carbamic acid tert-butyl ester
• CAS No.: 718619-72-8
• Molecular Formula: C₂₂H₂₃F₃IN₅O₃
• Molecular Weight: 589.356

Synonyms:(2-{5-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-phenyl]-[1,3,4]oxadiazol-2-ylamino}-ethyl)-methyl-carbamic acid tert-butyl ester

Chemical Property of (2-{5-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-phenyl]-[1,3,4]oxadiazol-2-ylamino}-ethyl)-methyl-carbamic acid tert-butyl ester

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Technology Process of (2-{5-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-phenyl]-[1,3,4]oxadiazol-2-ylamino}-ethyl)-methyl-carbamic acid tert-butyl ester

There total 1 articles about (2-{5-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-phenyl]-[1,3,4]oxadiazol-2-ylamino}-ethyl)-methyl-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4'-N-ethylcarbamic acid tert-butyl ester-1'-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)]-semicarbazole (718619-70-6) → (2-{5-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-phenyl]-[1,3,4]oxadiazol-2-ylamino}-ethyl)-methyl-carbamic acid tert-butyl ester (718619-72-8)

Guidance literature:

With tetrachloromethane; polystyrene-PPh₃; triethylamine; In dichloromethane; at 46 ℃; for 3h; Heating / reflux;

Reference yield:

(2-{5-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-phenyl]-[1,3,4]oxadiazol-2-ylamino}-ethyl)-methyl-carbamic acid tert-butyl ester (718619-72-8) → N-(5-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}-1,3,4-oxadiazol-2-yl)ethane-1,2-diamine (718618-00-9)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

(2-{5-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-phenyl]-[1,3,4]oxadiazol-2-ylamino}-ethyl)-methyl-carbamic acid tert-butyl ester (718619-72-8) → N-{5-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-phenyl]-[1,3,4]oxadiazol-2-yl}-N'-methyl-ethane-1,2-diamine hydrochloride salt

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 1h;

upstream raw materials:

4'-N-ethylcarbamic acid tert-butyl ester-1'-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)]-semicarbazole

Downstream raw materials:

2-(4-{2,3-difluoro-6-[5-(2-methylamino-ethylamino)-[1,3,4]oxadiazol-2-yl]-phenylamino}-3-fluoro-phenyl)-ethanol

N-(5-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}-1,3,4-oxadiazol-2-yl)ethane-1,2-diamine

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