N-benzyloxycarbonyl-N'-benzylguanidine

Base Information

• Chemical Name: N-benzyloxycarbonyl-N'-benzylguanidine
• CAS No.: 22102-72-3
• Molecular Formula: C₁₆H₁₇N₃O₂
• Molecular Weight: 283.33
• Mol file: 22102-72-3.mol

Synonyms:N-benzyloxycarbonyl-N'-benzylguanidine

Chemical Property of N-benzyloxycarbonyl-N'-benzylguanidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyloxycarbonyl-N'-benzylguanidine

There total 7 articles about N-benzyloxycarbonyl-N'-benzylguanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

C21H25N3O4 (1581260-84-5) → N-benzyloxycarbonyl-N'-benzylguanidine (22102-72-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1021/ol5002208

Reference yield:

benzylamine (100-46-9) → N-benzyloxycarbonyl-N'-benzylguanidine (22102-72-3)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / 0.25 h / 20 °C / Cooling with ice

2: tetrahydrofuran / 1 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ol5002208

Reference yield:

N-(Benzyloxycarbonyl)cyanamide (86554-53-2) → N-benzyloxycarbonyl-N'-benzylguanidine (22102-72-3)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium methanolate / methanol / 0.17 h / 0 °C / Inert atmosphere

2: acetonitrile / 0.17 h / 20 °C / Inert atmosphere

3: acetonitrile / 0.25 h / 20 °C / Inert atmosphere

With potassium methanolate; In methanol; acetonitrile;

DOI:10.1021/jo201264j

upstream raw materials:

benzylamine

N-(Benzyloxycarbonyl)cyanamide

benzyloxycarbonylcyanamide potassium salt

benzyl chloroformate

Refernces

• 1、 Maki, Toshikatsu,Tsuritani, Takayuki,Yasukata, Tatsuro. "A mild method for the synthesis of carbamate-protected guanidines using the burgess reagent". supporting information. p. 1868 - 1871. Retrieved 2014/05/06.