diethyl 2-<3-<2-chloro-6-fluoro-4-(trifluoromethyl)phenoxy>-6-nitrobenzyl>-2-methylmalonate

Base Information

• Chemical Name: diethyl 2-<3-<2-chloro-6-fluoro-4-(trifluoromethyl)phenoxy>-6-nitrobenzyl>-2-methylmalonate
• CAS No.: 154857-34-8
• Molecular Formula: C₂₂H₂₀ClF₄NO₇
• Molecular Weight: 521.85
• Mol file: 154857-34-8.mol

Synonyms:diethyl 2-<3-<2-chloro-6-fluoro-4-(trifluoromethyl)phenoxy>-6-nitrobenzyl>-2-methylmalonate

Chemical Property of diethyl 2-<3-<2-chloro-6-fluoro-4-(trifluoromethyl)phenoxy>-6-nitrobenzyl>-2-methylmalonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 2-<3-<2-chloro-6-fluoro-4-(trifluoromethyl)phenoxy>-6-nitrobenzyl>-2-methylmalonate

There total 1 articles about diethyl 2-<3-<2-chloro-6-fluoro-4-(trifluoromethyl)phenoxy>-6-nitrobenzyl>-2-methylmalonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Diethyl methylmalonate (609-08-5) + 3-<2-chloro-6-fluoro-4-(trifluoromethyl)phenoxy>-6-nitrobenzyl bromide → diethyl 2-<3-<2-chloro-6-fluoro-4-(trifluoromethyl)phenoxy>-6-nitrobenzyl>-2-methylmalonate (154857-34-8)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) DMF, 2.) DMF, RT, 2 h;

DOI:10.1021/jf00055a032

Reference yield: 90.0%

diethyl 2-<3-<2-chloro-6-fluoro-4-(trifluoromethyl)phenoxy>-6-nitrobenzyl>-2-methylmalonate (154857-34-8) → 6-<2-chloro-6-fluoro-4-(trifluoromethyl)phenoxy>-3-(ethoxycarbonyl)-3-methyl-1,2,3,4-tetrahydroquinolin-2-one (164415-40-1)

Guidance literature:

With hydrogen; nickel; In ethanol;

DOI:10.1021/jf00055a032

Reference yield:

diethyl 2-<3-<2-chloro-6-fluoro-4-(trifluoromethyl)phenoxy>-6-nitrobenzyl>-2-methylmalonate (154857-34-8) → 6-<2-chloro-6-fluoro-4-(trifluoromethyl)phenoxy>-1,3-dimethyl-1,2,3,4-tetrahydroquinolin-2-one

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / H₂ / Raney nickel / ethanol

2: 1.) NaH / 1.) DMF, 10 min, 2.) DMF, 10 min

3: 83 percent / 1 N aq. NaOH / ethanol / 2 h

With sodium hydroxide; hydrogen; sodium hydride; nickel; In ethanol;

DOI:10.1021/jf00055a032

upstream raw materials:

Diethyl methylmalonate

Downstream raw materials:

6-<2-chloro-6-fluoro-4-(trifluoromethyl)phenoxy>-3-(ethoxycarbonyl)-3-methyl-1,2,3,4-tetrahydroquinolin-2-one

6-<2-chloro-6-fluoro-4-(trifluoromethyl)phenoxy>-3-(ethoxycarbonyl)-1,3-dimethyl-1,2,3,4-tetrahydroquinolin-2-one