tert-butyl {4-[(2R,3R)-1-(4-chlorophenyl)-3-({[2-(4-chlorophenyl)-5,5-dimethyl-1,3-dioxan-2-yl]methyl}thio)-4-oxoazetidin-2-yl]phenoxy}acetate

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Chemical Name:tert-butyl {4-[(2R,3R)-1-(4-chlorophenyl)-3-({[2-(4-chlorophenyl)-5,5-dimethyl-1,3-dioxan-2-yl]methyl}thio)-4-oxoazetidin-2-yl]phenoxy}acetate
CAS No.:858104-32-2
Molecular Formula:C₃₄H₃₇Cl₂NO₆S
Molecular Weight:658.643
Hs Code.:

Synonyms:tert-butyl {4-[(2R,3R)-1-(4-chlorophenyl)-3-({[2-(4-chlorophenyl)-5,5-dimethyl-1,3-dioxan-2-yl]methyl}thio)-4-oxoazetidin-2-yl]phenoxy}acetate

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Chemical Property of tert-butyl {4-[(2R,3R)-1-(4-chlorophenyl)-3-({[2-(4-chlorophenyl)-5,5-dimethyl-1,3-dioxan-2-yl]methyl}thio)-4-oxoazetidin-2-yl]phenoxy}acetate

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Technology Process of tert-butyl {4-[(2R,3R)-1-(4-chlorophenyl)-3-({[2-(4-chlorophenyl)-5,5-dimethyl-1,3-dioxan-2-yl]methyl}thio)-4-oxoazetidin-2-yl]phenoxy}acetate

There total 10 articles about tert-butyl {4-[(2R,3R)-1-(4-chlorophenyl)-3-({[2-(4-chlorophenyl)-5,5-dimethyl-1,3-dioxan-2-yl]methyl}thio)-4-oxoazetidin-2-yl]phenoxy}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 858104-31-1
tert-butyl (4-{(1S,2R)-1-[(4-chlorophenyl)amino]-2-({[2-(4-chlorophenyl)-5,5-dimethyl-1,3-dioxan-2-yl]methyl}thio)-3-oxo-3-[(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl]propyl}phenoxy)acetate

: 858104-32-2
tert-butyl {4-[(2R,3R)-1-(4-chlorophenyl)-3-({[2-(4-chlorophenyl)-5,5-dimethyl-1,3-dioxan-2-yl]methyl}thio)-4-oxoazetidin-2-yl]phenoxy}acetate

Guidance literature:: tert-butyl (4-{(1S,2R)-1-[(4-chlorophenyl)amino]-2-({[2-(4-chlorophenyl)-5,5-dimethyl-1,3-dioxan-2-yl]methyl}thio)-3-oxo-3-[(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl]propyl}phenoxy)acetate; With N,O-bis-(trimethylsilyl)-acetamide; In toluene; at 90 ℃; for 1h;

With tetrabutyl ammonium fluoride; In toluene; at 20 - 45 ℃;

Reference yield:

: 858104-29-7
({[2-(4-chlorophenyl)-5,5-dimethyl-1,3-dioxan-2-yl]methyl}thio)acetic acid

: 858104-32-2
tert-butyl {4-[(2R,3R)-1-(4-chlorophenyl)-3-({[2-(4-chlorophenyl)-5,5-dimethyl-1,3-dioxan-2-yl]methyl}thio)-4-oxoazetidin-2-yl]phenoxy}acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0.33 h / 0 °C

1.2: 70 h / 20 °C

2.1: titanium(IV) isopropylate; titanium tetrachloride / dichloromethane / 0.92 h / 0 °C

2.2: 1.67 h / -40 - 0 °C

3.1: N,O-bis-(trimethylsilyl)-acetamide / toluene / 1 h / 90 °C

3.2: 20 - 45 °C

With titanium(IV) isopropylate; dmap; titanium tetrachloride; N,O-bis-(trimethylsilyl)-acetamide; dicyclohexyl-carbodiimide; In dichloromethane; toluene;

Reference yield:

: 858104-27-5
tert-butyl (4-{(E)-[(4-chlorophenyl)imino]methyl}phenoxy)acetate

: 858104-32-2
tert-butyl {4-[(2R,3R)-1-(4-chlorophenyl)-3-({[2-(4-chlorophenyl)-5,5-dimethyl-1,3-dioxan-2-yl]methyl}thio)-4-oxoazetidin-2-yl]phenoxy}acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: titanium(IV) isopropylate; titanium tetrachloride / dichloromethane / 0.92 h / 0 °C

1.2: 1.67 h / -40 - 0 °C

2.1: N,O-bis-(trimethylsilyl)-acetamide / toluene / 1 h / 90 °C

2.2: 20 - 45 °C

With titanium(IV) isopropylate; titanium tetrachloride; N,O-bis-(trimethylsilyl)-acetamide; In dichloromethane; toluene;