{4-[7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino]-phenyl}-morpholin-4-yl-methanone

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Chemical Name:{4-[7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino]-phenyl}-morpholin-4-yl-methanone
CAS No.:1232399-45-9
Molecular Formula:C₂₄H₂₃N₅O₃
Molecular Weight:429.478
Hs Code.:

Synonyms:{4-[7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino]-phenyl}-morpholin-4-yl-methanone

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Chemical Property of {4-[7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino]-phenyl}-morpholin-4-yl-methanone

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Technology Process of {4-[7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino]-phenyl}-morpholin-4-yl-methanone

There total 7 articles about {4-[7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino]-phenyl}-morpholin-4-yl-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1232816-20-4
7-(2-methoxyphenyl)-2-(methylsulfinyl)pyrrolo[2,1-f][1,2,4]triazine

: 51207-86-4
(4-amino-phenyl)-morpholin-4-yl-methanone

: 1232399-45-9
{4-[7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino]-phenyl}-morpholin-4-yl-methanone

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1-methoxy-2-propanol; at 180 ℃; Microwave irradiation;

Reference yield:

: 1233094-95-5
7-bromo-2-methylsulfanyl-pyrrolo[2,1-f][1,2,4]triazine

: 1232399-45-9
{4-[7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino]-phenyl}-morpholin-4-yl-methanone

Guidance literature:: Multi-step reaction with 5 steps

1: palladium diacetate; sodium carbonate; triphenylphosphine / tetrahydrofuran; ethanol; water / 80 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane

3: water; sodium hydroxide / 100 °C

4: N-ethyl-N,N-diisopropylamine / 1-methoxy-2-propanol

5: 1-methoxy-2-propanol / 50 °C

With water; palladium diacetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; ethanol; 1-methoxy-2-propanol; dichloromethane; water; 1: Suzuki coupling;
DOI:10.1016/j.bmcl.2011.10.032

Reference yield:

: 1233181-87-7
7-(2-methoxy-phenyl)-2-methylsulfanyl-pyrrolo[2,1-f][1,2,4]triazine

: 1232399-45-9
{4-[7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino]-phenyl}-morpholin-4-yl-methanone

Guidance literature:: Multi-step reaction with 4 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane

2: water; sodium hydroxide / 100 °C

3: N-ethyl-N,N-diisopropylamine / 1-methoxy-2-propanol

4: 1-methoxy-2-propanol / 50 °C

With water; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In 1-methoxy-2-propanol; dichloromethane;
DOI:10.1016/j.bmcl.2011.10.032