3-((3,5-bis(trifluoromethyl)phenyl)amino)-N,N-diethyl-2,3-dihydrofuro[3,2-b]pyridine-2-carboxamide

Base Information

• Chemical Name: 3-((3,5-bis(trifluoromethyl)phenyl)amino)-N,N-diethyl-2,3-dihydrofuro[3,2-b]pyridine-2-carboxamide
• CAS No.: 1431152-24-7
• Molecular Formula: C₂₀H₁₉F₆N₃O₂
• Molecular Weight: 447.38
• Mol file: 1431152-24-7.mol

Synonyms:3-((3,5-bis(trifluoromethyl)phenyl)amino)-N,N-diethyl-2,3-dihydrofuro[3,2-b]pyridine-2-carboxamide

Chemical Property of 3-((3,5-bis(trifluoromethyl)phenyl)amino)-N,N-diethyl-2,3-dihydrofuro[3,2-b]pyridine-2-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-((3,5-bis(trifluoromethyl)phenyl)amino)-N,N-diethyl-2,3-dihydrofuro[3,2-b]pyridine-2-carboxamide

There total 2 articles about 3-((3,5-bis(trifluoromethyl)phenyl)amino)-N,N-diethyl-2,3-dihydrofuro[3,2-b]pyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-2-(((3,5-bis(trifluoromethyl)phenyl)imino)methyl)pyridin-3-ol (1431151-71-1) + (diethylcarbamoyl)methyl-[(1R, 2S, 3R)-2-methoxy-1,7,7-trimethylbicyclo[2.2.1] hept-3-yl]methylsulfonium bromide → 3-((3,5-bis(trifluoromethyl)phenyl)amino)-N,N-diethyl-2,3-dihydrofuro[3,2-b]pyridine-2-carboxamide (1431152-24-7) + 3-((3,5-bis(trifluoromethyl)phenyl)amino)-N,N-diethyl-2,3-dihydrofuro[3,2-b]pyridine-2-carboxamide

Guidance literature:

(E)-2-(((3,5-bis(trifluoromethyl)phenyl)imino)methyl)pyridin-3-ol; (diethylcarbamoyl)methyl-[(1R, 2S, 3R)-2-methoxy-1,7,7-trimethylbicyclo[2.2.1] hept-3-yl]methylsulfonium bromide; In toluene; at 0 ℃; Molecular sieve;

With N,N,N',N'-tetramethylguanidine; In toluene; at 0 ℃; for 16h; Overall yield = 63%; Overall yield = 56.3 mg; enantioselective reaction; Molecular sieve;

DOI:10.1016/j.tet.2013.03.059

Reference yield:

2-Formyl-3-hydroxypyridin (1849-55-4) + 3,5-Bis-(trifluoromethyl)aniline (328-74-5) → 3-((3,5-bis(trifluoromethyl)phenyl)amino)-N,N-diethyl-2,3-dihydrofuro[3,2-b]pyridine-2-carboxamide (1431152-24-7) + 3-((3,5-bis(trifluoromethyl)phenyl)amino)-N,N-diethyl-2,3-dihydrofuro[3,2-b]pyridine-2-carboxamide

Guidance literature:

Multi-step reaction with 2 steps

1.1: ethanol / 2 h / 20 °C

2.1: toluene / 30?min / 0 °C / Molecular sieve

2.2: 16 h / 0 °C / Molecular sieve

In ethanol; toluene;

DOI:10.1016/j.tet.2013.03.059

upstream raw materials:

(E)-2-(((3,5-bis(trifluoromethyl)phenyl)imino)methyl)pyridin-3-ol

2-Formyl-3-hydroxypyridin

3,5-Bis-(trifluoromethyl)aniline