7-Amino-2-[2-(4-chloro-phenyl)-ethyl]-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

Base Information

Chemical Name:7-Amino-2-[2-(4-chloro-phenyl)-ethyl]-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
CAS No.:100987-59-5
Molecular Formula:C₁₃H₁₀ClN₅O₃S
Molecular Weight:351.773
Hs Code.:

Synonyms:7-Amino-2-[2-(4-chloro-phenyl)-ethyl]-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

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Chemical Property of 7-Amino-2-[2-(4-chloro-phenyl)-ethyl]-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

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Technology Process of 7-Amino-2-[2-(4-chloro-phenyl)-ethyl]-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

There total 5 articles about 7-Amino-2-[2-(4-chloro-phenyl)-ethyl]-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.1%

: 141422-08-4
7-Chloro-2-[2-(4-chloro-phenyl)-ethyl]-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

: 100987-59-5
7-Amino-2-[2-(4-chloro-phenyl)-ethyl]-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

Guidance literature:: With ammonium hydroxide; In 1,4-dioxane; at 60 ℃; for 0.25h;
DOI:10.1248/cpb.40.357

Reference yield:

: 32327-71-2
3-(4-chlorophenyl)propanenitrile

: 100987-59-5
7-Amino-2-[2-(4-chloro-phenyl)-ethyl]-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

Guidance literature:: Multi-step reaction with 5 steps

1: 76.9 percent / TFA / 6 h / 60 - 80 °C

2: 73.5 percent / Dowtherm A / 1 h / 120 - 130 °C

3: 92.2 percent / conc. HNO₃ / acetic acid / 2 h / Ambient temperature

4: 1.) POCl₃, 2.) PhNEt₂ / 1.) 70 - 90 deg C, 2.) 70 - 90 deg C, 3 h

5: 88.1 percent / conc. aq. NH₄OH / dioxane / 0.25 h / 60 °C

With ammonium hydroxide; diphenyl ether-biphenyl eutectic; nitric acid; trifluoroacetic acid; N,N-diethylaniline; trichlorophosphate; In 1,4-dioxane; acetic acid;
DOI:10.1248/cpb.40.357

Reference yield:

: 100988-18-9
5-[2-(4-chloro-phenyl)ethyl]-[1 ,3,4]thiadiazol-2-ylamine

: 100987-59-5
7-Amino-2-[2-(4-chloro-phenyl)-ethyl]-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

Guidance literature:: Multi-step reaction with 4 steps

1: 73.5 percent / Dowtherm A / 1 h / 120 - 130 °C

2: 92.2 percent / conc. HNO₃ / acetic acid / 2 h / Ambient temperature

3: 1.) POCl₃, 2.) PhNEt₂ / 1.) 70 - 90 deg C, 2.) 70 - 90 deg C, 3 h

4: 88.1 percent / conc. aq. NH₄OH / dioxane / 0.25 h / 60 °C

With ammonium hydroxide; diphenyl ether-biphenyl eutectic; nitric acid; N,N-diethylaniline; trichlorophosphate; In 1,4-dioxane; acetic acid;
DOI:10.1248/cpb.40.357