7-[(4E)-3-(aminomethyl)-4-methoxyiminopyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid

Base Information Edit

Chemical Name:7-[(4E)-3-(aminomethyl)-4-methoxyiminopyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid
CAS No.:175463-14-6
Molecular Formula:C18H20FN5O4
Molecular Weight:389.386
Hs Code.:2933990090
DSSTox Substance ID:DTXSID901102042
Nikkaji Number:J726.319H
Wikipedia:Gemifloxacin
Wikidata:Q1639595
Mol file:175463-14-6.mol

Synonyms:7-(3-aminomethyl-4-methoxyimino-pyrrolidine-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-(1,8)-naphthyridine-3-carboxylic acid;Factive;gemifloxacin;gemifloxacin mesylate;LB 20304;LB-20304;LB20304;SB 265805;SB-265805;SB265805

Suppliers and Price of 7-[(4E)-3-(aminomethyl)-4-methoxyiminopyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Gemifloxacin mesilate
10mg
$ 326.00

Biorbyt Ltd
Gemifioxacin >98%
100 mg
$ 690.20

AvaChem
Gemifloxacin
1g
$ 245.00

AvaChem
Gemifloxacin
100mg
$ 95.00

AvaChem
Gemifloxacin
10mg
$ 45.00

AvaChem
Gemifloxacin
5g
$ 985.00

American Custom Chemicals Corporation
GEMIFLOXACIN 95.00%
25MG
$ 1224.88

American Custom Chemicals Corporation
GEMIFLOXACIN 95.00%
5MG
$ 754.68

American Custom Chemicals Corporation
GEMIFLOXACIN 95.00%
1MG
$ 584.55

AHH
Gemifloxacin 98%
10g
$ 910.00

Total 112 raw suppliers

Chemical Property of 7-[(4E)-3-(aminomethyl)-4-methoxyiminopyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid Edit

Chemical Property:

Appearance/Colour:powder
Vapor Pressure:0mmHg at 25°C
Melting Point:235-237°
Refractive Index:1.735
Boiling Point:638.919 °C at 760 mmHg
PKA:6.02±0.70(Predicted)
Flash Point:340.206 °C
PSA：123.04000
Density:1.648 g/cm³
LogP:1.73130
XLogP3:-0.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:5
Exact Mass:389.14993230
Heavy Atom Count:28
Complexity:725

Purity/Quality:

98%,99%, ^*data from raw suppliers

Gemifloxacin mesilate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CON=C1CN(CC1CN)C2=C(C=C3C(=O)C(=CN(C3=N2)C4CC4)C(=O)O)F
Isomeric SMILES:CO/N=C\1/CN(CC1CN)C2=C(C=C3C(=O)C(=CN(C3=N2)C4CC4)C(=O)O)F
Description LG Life Sciences (formerly LG Chemical) has developed gemifloxacin (SB-265805, LB-20304a), a fluoronaphthyridone active against both Gram-positive and Gram-negative bacteria, including methicillin-resistant staphylococci, as a treatment for bacterial infection. By December 2002, the drug had been approved in Korea.
Clinical Use Community-acquired pneumonia in adults Acute exacerbations of chronic bronchitis in adults

Technology Process of 7-[(4E)-3-(aminomethyl)-4-methoxyiminopyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid

There total 11 articles about 7-[(4E)-3-(aminomethyl)-4-methoxyiminopyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%