1,7,8-triaza-3,3,6,6-tetramethyl-5-oxa-2-oxo-1-(p-bromophenyl)spiro[3,4]oct-7-ene

Base Information

• Chemical Name: 1,7,8-triaza-3,3,6,6-tetramethyl-5-oxa-2-oxo-1-(p-bromophenyl)spiro[3,4]oct-7-ene
• CAS No.: 896745-99-6
• Molecular Formula: C₁₄H₁₆BrN₃O₂
• Molecular Weight: 338.204

Synonyms:1,7,8-triaza-3,3,6,6-tetramethyl-5-oxa-2-oxo-1-(p-bromophenyl)spiro[3,4]oct-7-ene

Chemical Property of 1,7,8-triaza-3,3,6,6-tetramethyl-5-oxa-2-oxo-1-(p-bromophenyl)spiro[3,4]oct-7-ene

Chemical Property:

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Technology Process of 1,7,8-triaza-3,3,6,6-tetramethyl-5-oxa-2-oxo-1-(p-bromophenyl)spiro[3,4]oct-7-ene

There total 1 articles about 1,7,8-triaza-3,3,6,6-tetramethyl-5-oxa-2-oxo-1-(p-bromophenyl)spiro[3,4]oct-7-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

isobutyryl chloride (79-30-1) + (4-bromo-phenyl)-(5,5-dimethyl-5H-[1,3,4]oxadiazol-2-ylidene)-amine (53340-73-1) → 1,7,8-triaza-3,3,6,6-tetramethyl-5-oxa-2-oxo-1-(p-bromophenyl)spiro[3,4]oct-7-ene (896745-99-6)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1021/jo060265h

Reference yield: 84.0%

1,7,8-triaza-3,3,6,6-tetramethyl-5-oxa-2-oxo-1-(p-bromophenyl)spiro[3,4]oct-7-ene (896745-99-6) + 3,6-diphenyl-1,2,4,5-tetrazine (6830-78-0) → 1-(4-bromophenyl)-3,3-dimethyl-8-phenyl-3,8-dihydroindeno[2,1-b]pyrrol-2-one (1303541-30-1)

Guidance literature:

In toluene; for 10h; Inert atmosphere; Reflux;

DOI:10.1021/jo200499u

Reference yield: 81.0%

1,7,8-triaza-3,3,6,6-tetramethyl-5-oxa-2-oxo-1-(p-bromophenyl)spiro[3,4]oct-7-ene (896745-99-6) + p-chlorophenyl isocyanide (1885-81-0) → 5-chloro-1-[3,3-dimethyl-2-oxo-1-(p-bromophenyl)azetidin-4-yl]-2-[(Z)-3,3-dimethyl-2-oxo-1-(p-bromophenyl)azetidin-4-ylidene]-3-(p-chlorophenylimino)-2,3-dihydroindole

Guidance literature:

In 1,4-dioxane; for 10h; Heating;

DOI:10.1021/jo0700631

upstream raw materials:

isobutyryl chloride

(4-bromo-phenyl)-(5,5-dimethyl-5H-[1,3,4]oxadiazol-2-ylidene)-amine

Downstream raw materials:

(RS,SR)-2'-(3'',3''-dimethyl-1''-bromophenylazetidin-2''-one)-oxy-3,3,5'-trimethyl-1-bromophenylspiro[azetidine-4,3'-indoline]-2-one

(RS,RS)-2'-(3'',3''-dimethyl-1''-bromophenylazetidin-2''-one)-oxy-3,3,5'-trimethyl-1-bromophenylspiro[azetidine-4,3'-indoline]-2-one

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