6-[3-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-2-hydroxypropylamino]purine

Base Information

Chemical Name:6-[3-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-2-hydroxypropylamino]purine
CAS No.:125346-13-6
Molecular Formula:C₂₅H₂₇F₂N₇O
Molecular Weight:479.532
Hs Code.:

Synonyms:6-[3-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-2-hydroxypropylamino]purine

Suppliers and Price of 6-[3-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-2-hydroxypropylamino]purine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-[3-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-2-hydroxypropylamino]purine

Chemical Property:

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Technology Process of 6-[3-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-2-hydroxypropylamino]purine

There total 4 articles about 6-[3-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-2-hydroxypropylamino]purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 87-42-3,111055-92-6
6-chloro-7H-purine

: 125345-90-6
1-amino-3-[4-[bis(4-fluorophenyl)-methyl]-1-piperazinyl]-2-propanol

: 125346-13-6
4--α-<(9H-purin-6-ylamino)methyl>-1-piperazineethanol

Guidance literature:: With triethylamine; In methanol; for 168h; Heating;
DOI:10.1021/jm00102a001

Reference yield:

: 125345-90-6
1-amino-3-[4-[bis(4-fluorophenyl)-methyl]-1-piperazinyl]-2-propanol

: 87-42-3
6-chloropurine

: 125346-13-6
6-[3-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-2-hydroxypropylamino]purine

Guidance literature:: With triethylamine; In methanol; CHC₃;

Reference yield:

: 125345-89-3
1-<1-(2,3-epoxypropyl)>-4-piperazine

: 125346-13-6
4--α-<(9H-purin-6-ylamino)methyl>-1-piperazineethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 61 percent / NH₃ / ethanol / 28 h / 110 °C

2: 70 percent / Et₃N / methanol / 168 h / Heating

With ammonia; triethylamine; In methanol; ethanol;
DOI:10.1021/jm00102a001