4'-[3-(2,4-diamino-6-ethyl-pyrimidin-5-yl)-1-methyl-prop-2-ynyl]-3'-methoxy-biphenyl-4-ol

Base Information

Chemical Name:4'-[3-(2,4-diamino-6-ethyl-pyrimidin-5-yl)-1-methyl-prop-2-ynyl]-3'-methoxy-biphenyl-4-ol
CAS No.:1569901-94-5
Molecular Formula:C₂₃H₂₄N₄O₂
Molecular Weight:388.469
Hs Code.:

Synonyms:4'-[3-(2,4-diamino-6-ethyl-pyrimidin-5-yl)-1-methyl-prop-2-ynyl]-3'-methoxy-biphenyl-4-ol

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Chemical Property of 4'-[3-(2,4-diamino-6-ethyl-pyrimidin-5-yl)-1-methyl-prop-2-ynyl]-3'-methoxy-biphenyl-4-ol

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Technology Process of 4'-[3-(2,4-diamino-6-ethyl-pyrimidin-5-yl)-1-methyl-prop-2-ynyl]-3'-methoxy-biphenyl-4-ol

There total 7 articles about 4'-[3-(2,4-diamino-6-ethyl-pyrimidin-5-yl)-1-methyl-prop-2-ynyl]-3'-methoxy-biphenyl-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1569901-84-3
3'-methoxy-4'-(1-methyl-prop-2-ynyl)-biphenyl-4-ol

: 514854-13-8
2,4-diamino-6-ethyl-5-iodopyrimidine

: 1569901-94-5
4'-[3-(2,4-diamino-6-ethyl-pyrimidin-5-yl)-1-methyl-prop-2-ynyl]-3'-methoxy-biphenyl-4-ol

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In N,N-dimethyl-formamide; at 60 ℃; for 14h; Inert atmosphere; Sealed tube;
DOI:10.1021/jm401916j

Reference yield:

: 2-{4-[4-(but-3-yn-2-yl)-3-methoxyphenyl]phenoxy}oxane

: 1569901-94-5
4'-[3-(2,4-diamino-6-ethyl-pyrimidin-5-yl)-1-methyl-prop-2-ynyl]-3'-methoxy-biphenyl-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1: methanol; toluene-4-sulfonic acid / 0 - 20 °C

2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 14 h / 60 °C / Inert atmosphere; Sealed tube

With methanol; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; toluene-4-sulfonic acid; triethylamine; In N,N-dimethyl-formamide; 2: |Sonogashira Cross-Coupling;
DOI:10.1021/jm401916j

Reference yield:

: 89368-12-7
1-[4-bromo-2-(methyloxy)phenyl]ethanone

: 1569901-94-5
4'-[3-(2,4-diamino-6-ethyl-pyrimidin-5-yl)-1-methyl-prop-2-ynyl]-3'-methoxy-biphenyl-4-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 14 h / 80 °C / Inert atmosphere; Sealed tube

2.1: sodium t-butanolate / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

2.2: 0.33 h / Inert atmosphere

3.1: mercury(II) diacetate / water; tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

3.2: 0.25 h / 20 °C / Inert atmosphere

4.1: potassium carbonate / methanol / 2 h / 0 °C / Inert atmosphere

5.1: methanol; toluene-4-sulfonic acid / 0 - 20 °C

6.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 14 h / 60 °C / Inert atmosphere; Sealed tube

With methanol; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; mercury(II) diacetate; potassium carbonate; caesium carbonate; toluene-4-sulfonic acid; triethylamine; sodium t-butanolate; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; 1.1: |Suzuki Coupling / 2.1: |Wittig Olefination / 2.2: |Wittig Olefination / 6.1: |Sonogashira Cross-Coupling;
DOI:10.1021/jm401916j