1,1-dimethylethyl3-[2-(2-{[(4-bromo-2-fluorophenyl)amino]carbonyl}hydrazino)-2-oxoethyl]-1-azetidinecarboxylate

Base Information

Chemical Name:1,1-dimethylethyl3-[2-(2-{[(4-bromo-2-fluorophenyl)amino]carbonyl}hydrazino)-2-oxoethyl]-1-azetidinecarboxylate
CAS No.:1332333-68-2
Molecular Formula:C₁₇H₂₂BrFN₄O₄
Molecular Weight:445.288
Hs Code.:

Synonyms:1,1-dimethylethyl3-[2-(2-{[(4-bromo-2-fluorophenyl)amino]carbonyl}hydrazino)-2-oxoethyl]-1-azetidinecarboxylate

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Chemical Property of 1,1-dimethylethyl3-[2-(2-{[(4-bromo-2-fluorophenyl)amino]carbonyl}hydrazino)-2-oxoethyl]-1-azetidinecarboxylate

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Technology Process of 1,1-dimethylethyl3-[2-(2-{[(4-bromo-2-fluorophenyl)amino]carbonyl}hydrazino)-2-oxoethyl]-1-azetidinecarboxylate

There total 1 articles about 1,1-dimethylethyl3-[2-(2-{[(4-bromo-2-fluorophenyl)amino]carbonyl}hydrazino)-2-oxoethyl]-1-azetidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332333-67-1
3-hydrazinocarbonylmethylazetidine-1-carboxylic acid tert-butyl ester

: 88112-75-8
4-bromo-2-fluorophenyl isocyanate

: 1332333-68-2
1,1-dimethylethyl3-[2-(2-{[(4-bromo-2-fluorophenyl)amino]carbonyl}hydrazino)-2-oxoethyl]-1-azetidinecarboxylate

Guidance literature:: In dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield:

: 1332333-68-2
1,1-dimethylethyl3-[2-(2-{[(4-bromo-2-fluorophenyl)amino]carbonyl}hydrazino)-2-oxoethyl]-1-azetidinecarboxylate

: 1332333-69-3
C₁₅H₁₆BrFN₄O₂

Guidance literature:: With potassium carbonate; In propan-1-ol; water; at 130 ℃; for 43h;

Reference yield:

: 1332333-68-2
1,1-dimethylethyl3-[2-(2-{[(4-bromo-2-fluorophenyl)amino]carbonyl}hydrazino)-2-oxoethyl]-1-azetidinecarboxylate

: 1332332-71-4
4-[2-fluoro-4-(7-quinolinyl)phenyl]-5-[(1-propanoyl-3-azetidinyl)methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / water; propan-1-ol / 43 h / 130 °C

2.1: sodium hydroxide; di-tert-butyl dicarbonate / water

2.2: 0.08 h / 20 °C

2.3: 1 h / 20 °C

3.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 1 h / 100 °C / Inert atmosphere; Sealed tube; Microwave irradiation

With di-tert-butyl dicarbonate; potassium carbonate; sodium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; propan-1-ol; water;