methyl N-benzyl-2-(2-methoxycarbonylethyl)-4-oxoazetidine-2-carboxylate

Base Information

Chemical Name:methyl N-benzyl-2-(2-methoxycarbonylethyl)-4-oxoazetidine-2-carboxylate
CAS No.:1376574-20-7
Molecular Formula:C₁₆H₁₉NO₅
Molecular Weight:305.331
Hs Code.:

Synonyms:methyl N-benzyl-2-(2-methoxycarbonylethyl)-4-oxoazetidine-2-carboxylate

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Chemical Property of methyl N-benzyl-2-(2-methoxycarbonylethyl)-4-oxoazetidine-2-carboxylate

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Technology Process of methyl N-benzyl-2-(2-methoxycarbonylethyl)-4-oxoazetidine-2-carboxylate

There total 1 articles about methyl N-benzyl-2-(2-methoxycarbonylethyl)-4-oxoazetidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 269717-62-6
dimethyl (-)-(S)-2-[N-benzyl-N-(2-chloroacetyl)amino]pentanedioate

: 1376574-20-7
methyl N-benzyl-2-(2-methoxycarbonylethyl)-4-oxoazetidine-2-carboxylate

Guidance literature:: With caesium carbonate; In acetonitrile; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2012.03.111

Reference yield: 81.0%

: 27607-77-8
trimethylsilyl trifluoromethanesulfonate

: 1376574-20-7
methyl N-benzyl-2-(2-methoxycarbonylethyl)-4-oxoazetidine-2-carboxylate

: methyl (1S*,5S*)-6-benzyl-2,7-dioxo-6-azabicyclo[3.2.0]heptane-5-carboxylate

Guidance literature:: trimethylsilyl trifluoromethanesulfonate; methyl N-benzyl-2-(2-methoxycarbonylethyl)-4-oxoazetidine-2-carboxylate; With triethylamine; In dichloromethane; at 0 - 20 ℃; for 24h; Inert atmosphere;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 24h; Reagent/catalyst; Time; Inert atmosphere;
DOI:10.1039/c8ob01065j

Reference yield:

: 1376574-20-7
methyl N-benzyl-2-(2-methoxycarbonylethyl)-4-oxoazetidine-2-carboxylate

: rac-(1S,5S)-N-benzyl-5-(hydroxymethyl)-6-azabicyclo[3.2.0]heptan-2,7-dione

Guidance literature:: methyl N-benzyl-2-(2-methoxycarbonylethyl)-4-oxoazetidine-2-carboxylate; With trimethylsilyl trifluoromethanesulfonate; triethylamine; In dichloromethane; at 0 - 20 ℃; for 24h; Inert atmosphere;

With lithium borohydride; In diethyl ether; at 20 ℃; for 8h; Inert atmosphere;

With hydrogenchloride; water; In tetrahydrofuran; at 20 ℃; for 5h; diastereoselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2012.03.111