(R)-2-(4-((5-(ethylsulfonyl)-1H-pyrroio[2,3-c]pyridin-2-yl)methyl)-5,5,5-trifluoro-4-hydroxy-2-methylpentan-2-yl)-5-fluorobenzamide

Base Information

Chemical Name:(R)-2-(4-((5-(ethylsulfonyl)-1H-pyrroio[2,3-c]pyridin-2-yl)methyl)-5,5,5-trifluoro-4-hydroxy-2-methylpentan-2-yl)-5-fluorobenzamide
CAS No.:1198784-72-3
Molecular Formula:C₂₃H₂₅F₄N₃O₄S
Molecular Weight:515.529
Hs Code.:

Synonyms:(R)-2-(4-((5-(ethylsulfonyl)-1H-pyrroio[2,3-c]pyridin-2-yl)methyl)-5,5,5-trifluoro-4-hydroxy-2-methylpentan-2-yl)-5-fluorobenzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-(4-((5-(ethylsulfonyl)-1H-pyrroio[2,3-c]pyridin-2-yl)methyl)-5,5,5-trifluoro-4-hydroxy-2-methylpentan-2-yl)-5-fluorobenzamide

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of (R)-2-(4-((5-(ethylsulfonyl)-1H-pyrroio[2,3-c]pyridin-2-yl)methyl)-5,5,5-trifluoro-4-hydroxy-2-methylpentan-2-yl)-5-fluorobenzamide

There total 11 articles about (R)-2-(4-((5-(ethylsulfonyl)-1H-pyrroio[2,3-c]pyridin-2-yl)methyl)-5,5,5-trifluoro-4-hydroxy-2-methylpentan-2-yl)-5-fluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.1%

: 1198785-56-6
2-((R)-4-((5-(ethylsulfonyl)-1H-pyrrolo[2,3-c]pyridin-2-yl)methyl)-5,5,5-trifluoro-4-hydroxy-2-methylpentan-2-yl)-5-fluoro-N-((S)-1-(4-methoxyphenyl)ethyl)benzamide

: 1198784-72-3
(R)-2-(4-((5-(ethylsulfonyl)-1H-pyrroio[2,3-c]pyridin-2-yl)methyl)-5,5,5-trifluoro-4-hydroxy-2-methylpentan-2-yl)-5-fluorobenzamide

Guidance literature:: With phosphoric acid; In water; methoxybenzene; at 100 ℃;

Reference yield:

: 52025-15-7
6-(ethylthio)pyridin-3-amine

: 1198784-72-3
(R)-2-(4-((5-(ethylsulfonyl)-1H-pyrroio[2,3-c]pyridin-2-yl)methyl)-5,5,5-trifluoro-4-hydroxy-2-methylpentan-2-yl)-5-fluorobenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol / 18 h / 20 °C

2.1: sodium periodate / ruthenium trichloride / water; acetonitrile / 0.5 h / 20 °C

3.1: 1,4-diaza-bicyclo[2.2.2]octane / palladium diacetate / methanol / 50 °C / Inert atmosphere

3.2: 50 - 53 °C

4.1: phosphoric acid / water; methoxybenzene / 100 °C

With 1,4-diaza-bicyclo[2.2.2]octane; sodium periodate; phosphoric acid; ruthenium trichloride; palladium diacetate; In methanol; ethanol; water; methoxybenzene; acetonitrile;

Reference yield:

: 4548-45-2
2-chloro-5-nitropyridine

: 1198784-72-3
(R)-2-(4-((5-(ethylsulfonyl)-1H-pyrroio[2,3-c]pyridin-2-yl)methyl)-5,5,5-trifluoro-4-hydroxy-2-methylpentan-2-yl)-5-fluorobenzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran; water / 2 h / 0 - 5 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 h / 2585.81 Torr

3.1: ethanol / 18 h / 20 °C

4.1: sodium periodate / ruthenium trichloride / water; acetonitrile / 0.5 h / 20 °C

5.1: 1,4-diaza-bicyclo[2.2.2]octane / palladium diacetate / methanol / 50 °C / Inert atmosphere

5.2: 50 - 53 °C

6.1: phosphoric acid / water; methoxybenzene / 100 °C

With 1,4-diaza-bicyclo[2.2.2]octane; sodium periodate; phosphoric acid; hydrogen; ruthenium trichloride; palladium 10% on activated carbon; palladium diacetate; In tetrahydrofuran; methanol; ethanol; water; methoxybenzene; acetonitrile;