4-(3-(4-(trifluoromethyl)phenoxy)propoxy)phenyl dimethylcarbamate

Base Information

• Chemical Name: 4-(3-(4-(trifluoromethyl)phenoxy)propoxy)phenyl dimethylcarbamate
• CAS No.: 1257802-74-6
• Molecular Formula: C₁₉H₂₀F₃NO₄
• Molecular Weight: 383.367
• Mol file: 1257802-74-6.mol

Synonyms:4-(3-(4-(trifluoromethyl)phenoxy)propoxy)phenyl dimethylcarbamate

Chemical Property of 4-(3-(4-(trifluoromethyl)phenoxy)propoxy)phenyl dimethylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 4-(3-(4-(trifluoromethyl)phenoxy)propoxy)phenyl dimethylcarbamate

There total 3 articles about 4-(3-(4-(trifluoromethyl)phenoxy)propoxy)phenyl dimethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.1%

4-(3-(4-(trifluoromethyl)phenoxy)propoxy)phenol (1257803-21-6) + N,N-Dimethylcarbamoyl chloride (79-44-7) → 4-(3-(4-(trifluoromethyl)phenoxy)propoxy)phenyl dimethylcarbamate (1257802-74-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 8h;

DOI:10.1021/jf1032284

Reference yield:

1-(3-bromopropoxy)-4-(trifluoromethyl)benzene (169450-49-1) → 4-(3-(4-(trifluoromethyl)phenoxy)propoxy)phenyl dimethylcarbamate (1257802-74-6)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 24 h / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 8 h / 20 °C

With potassium carbonate; In N,N-dimethyl-formamide; acetone;

DOI:10.1021/jf1032284

Reference yield:

4-hydroxybenzotrifluoride (402-45-9) → 4-(3-(4-(trifluoromethyl)phenoxy)propoxy)phenyl dimethylcarbamate (1257802-74-6)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 16 h / Reflux

2: potassium carbonate / acetone / 24 h / Reflux

3: potassium carbonate / N,N-dimethyl-formamide / 8 h / 20 °C

With potassium carbonate; In N,N-dimethyl-formamide; acetone;

DOI:10.1021/jf1032284

upstream raw materials:

4-(3-(4-(trifluoromethyl)phenoxy)propoxy)phenol

N,N-Dimethylcarbamoyl chloride

4-hydroxybenzotrifluoride

1-(3-bromopropoxy)-4-(trifluoromethyl)benzene