(2S,4S)-tert-butyl 2-(4 (2'-chloro-4'-((6-((R)-2-methyl-4-pivaloylpiperazin-1-yl)pyridin-3-yl)carbamoyl)-6'-(trifluoomethoxy)-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)-4-methylpyrrolidine-1-carboxylate

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Chemical Name:(2S,4S)-tert-butyl 2-(4 (2'-chloro-4'-((6-((R)-2-methyl-4-pivaloylpiperazin-1-yl)pyridin-3-yl)carbamoyl)-6'-(trifluoomethoxy)-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)-4-methylpyrrolidine-1-carboxylate
CAS No.:1433281-30-1
Molecular Formula:C₄₂H₄₉ClF₃N₇O₅
Molecular Weight:824.343
Hs Code.:

(2S,4S)-tert-butyl 2-(4 (2'-chloro-4'-((6-((R)-2-methyl-4-pivaloylpiperazin-1-yl)pyridin-3-yl)carbamoyl)-6'-(trifluoomethoxy)-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)-4-methylpyrrolidine-1-carboxylate

Synonyms:(2S,4S)-tert-butyl 2-(4 (2'-chloro-4'-((6-((R)-2-methyl-4-pivaloylpiperazin-1-yl)pyridin-3-yl)carbamoyl)-6'-(trifluoomethoxy)-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)-4-methylpyrrolidine-1-carboxylate

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Chemical Property of (2S,4S)-tert-butyl 2-(4 (2'-chloro-4'-((6-((R)-2-methyl-4-pivaloylpiperazin-1-yl)pyridin-3-yl)carbamoyl)-6'-(trifluoomethoxy)-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)-4-methylpyrrolidine-1-carboxylate

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Technology Process of (2S,4S)-tert-butyl 2-(4 (2'-chloro-4'-((6-((R)-2-methyl-4-pivaloylpiperazin-1-yl)pyridin-3-yl)carbamoyl)-6'-(trifluoomethoxy)-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)-4-methylpyrrolidine-1-carboxylate

There total 15 articles about (2S,4S)-tert-butyl 2-(4 (2'-chloro-4'-((6-((R)-2-methyl-4-pivaloylpiperazin-1-yl)pyridin-3-yl)carbamoyl)-6'-(trifluoomethoxy)-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)-4-methylpyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1307310-41-3
(2S,4S)-4-methyl-2-{4-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-1H-imidazol-2-yl}-pyrrolidine-1-carboxylic acid tert-butyl ester

: 1433280-62-6
(R)-4-bromo-3-chloro-N-(6-(2-methyl-4-pivaloylpiperazin-1-yl)pyridin-3-yl)-5-(trifluoromethoxy)benzamide

: 1433281-30-1
(2S,4S)-tert-butyl 2-(4 (2'-chloro-4'-((6-((R)-2-methyl-4-pivaloylpiperazin-1-yl)pyridin-3-yl)carbamoyl)-6'-(trifluoomethoxy)-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)-4-methylpyrrolidine-1-carboxylate

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In water; toluene; at 100 ℃; Sealed tube;

Reference yield:

: 175278-22-5
4-amino-3-(trifluoromethoxy)benzoic acid

: 1433281-30-1
(2S,4S)-tert-butyl 2-(4 (2'-chloro-4'-((6-((R)-2-methyl-4-pivaloylpiperazin-1-yl)pyridin-3-yl)carbamoyl)-6'-(trifluoomethoxy)-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)-4-methylpyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogenchloride / 1,4-dioxane / 20 °C

2.1: N-chloro-succinimide / acetonitrile; N,N-dimethyl acetamide / 1 h / 20 - 60 °C

3.1: tert.-butylnitrite; copper(ll) bromide / acetonitrile; water / 1 h / 20 - 60 °C

4.1: water; lithium hydroxide / methanol / 0.5 h / 75 °C

4.2: pH Ca_. 1

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl acetamide / 1 h / 20 °C

6.1: hydrogenchloride / 1,4-dioxane / 20 °C

7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 20 °C

8.1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; toluene / 100 °C / Sealed tube

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-chloro-succinimide; tert.-butylnitrite; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; copper(ll) bromide; lithium hydroxide; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl acetamide; water; toluene; acetonitrile;

Reference yield:

: 4548-45-2
2-chloro-5-nitropyridine

: 1433281-30-1
(2S,4S)-tert-butyl 2-(4 (2'-chloro-4'-((6-((R)-2-methyl-4-pivaloylpiperazin-1-yl)pyridin-3-yl)carbamoyl)-6'-(trifluoomethoxy)-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)-4-methylpyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / dimethyl sulfoxide / 100 °C

2: hydrogen; 20% palladium hydroxide-activated charcoal / methanol

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl acetamide / 1 h / 20 °C

4: hydrogenchloride / 1,4-dioxane / 20 °C

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 20 °C

6: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; toluene / 100 °C / Sealed tube

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 20% palladium hydroxide-activated charcoal; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl acetamide; water; dimethyl sulfoxide; toluene;