cyclo-(β,β-diethyl-β-mercaptopropionyl)-Phe(NO2)-Phe-Val-Asn-Cys-Pro-Lys-D-Tyr-NH2

Base Information

• Chemical Name: cyclo-(β,β-diethyl-β-mercaptopropionyl)-Phe(NO2)-Phe-Val-Asn-Cys-Pro-Lys-D-Tyr-NH2
• CAS No.: 138754-04-8
• Molecular Formula: C₅₇H₇₈N₁₂O₁₃S₂
• Molecular Weight: 1203.45
• Mol file: 138754-04-8.mol

Synonyms:cyclo-(β,β-diethyl-β-mercaptopropionyl)-Phe(NO2)-Phe-Val-Asn-Cys-Pro-Lys-D-Tyr-NH2

Chemical Property of cyclo-(β,β-diethyl-β-mercaptopropionyl)-Phe(NO2)-Phe-Val-Asn-Cys-Pro-Lys-D-Tyr-NH2

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cyclo-(β,β-diethyl-β-mercaptopropionyl)-Phe(NO2)-Phe-Val-Asn-Cys-Pro-Lys-D-Tyr-NH2

There total 1 articles about cyclo-(β,β-diethyl-β-mercaptopropionyl)-Phe(NO2)-Phe-Val-Asn-Cys-Pro-Lys-D-Tyr-NH2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(tert-butoxycarbonyl)-L-proline (15761-39-4,59433-50-0) + N-tert-butyloxycarbonylasparagine (7536-55-2) + Boc-Phe(p-NO2)-OH (33305-77-0) + β,β-diethyl-S-(4-methylbenzyl)-β-mercaptopropionic acid (104532-41-4) → cyclo-(β,β-diethyl-β-mercaptopropionyl)-Phe(NO2)-Phe-Val-Asn-Cys-Pro-Lys-D-Tyr-NH2 (138754-04-8)

Guidance literature:

Yield given. Multistep reaction;

DOI:10.1021/jm00079a020

Reference yield:

cyclo-(β,β-diethyl-β-mercaptopropionyl)-Phe(NO2)-Phe-Val-Asn-Cys-Pro-Lys-D-Tyr-NH2 (138754-04-8) → C57H80N12O11S2

Guidance literature:

With hydrogen; acetic acid; palladium on activated charcoal; for 1h; under 6080 Torr;

DOI:10.1021/jm00079a020

Reference yield:

cyclo-(β,β-diethyl-β-mercaptopropionyl)-Phe(NO2)-Phe-Val-Asn-Cys-Pro-Lys-D-Tyr-NH2 (138754-04-8) → cyclo-(β,β-diethyl-β-mercaptopropionyl)-Phe(N3)-Phe-Val-Asn-Cys-Pro-Lys-D-Tyr-NH2

Guidance literature:

Multi-step reaction with 2 steps

1: H₂, 2N HOAc / Pd/C / 1 h / 6080 Torr

2: 1.) 1N HOAC, β-mercaptoethanol, 2.) 0,1N HCl, 1N NaNO2, NaN3

With hydrogenchloride; sodium azide; hydrogen; acetic acid; 2-hydroxyethanethiol; sodium nitrite; palladium on activated charcoal;

DOI:10.1021/jm00079a020

upstream raw materials:

1-(tert-butoxycarbonyl)-L-proline

N-tert-butyloxycarbonylasparagine

Boc-Phe(p-NO₂)-OH

β,β-diethyl-S-(4-methylbenzyl)-β-mercaptopropionic acid