2-[2-(4-Cyano-benzenesulfonylamino)-acetylamino]-3-(3-cyano-phenyl)-propionic acid

Base Information

• Chemical Name: 2-[2-(4-Cyano-benzenesulfonylamino)-acetylamino]-3-(3-cyano-phenyl)-propionic acid
• CAS No.: 214843-45-5
• Molecular Formula: C₁₉H₁₆N₄O₅S
• Molecular Weight: 412.426
• Mol file: 214843-45-5.mol

Synonyms:2-[2-(4-Cyano-benzenesulfonylamino)-acetylamino]-3-(3-cyano-phenyl)-propionic acid

Chemical Property of 2-[2-(4-Cyano-benzenesulfonylamino)-acetylamino]-3-(3-cyano-phenyl)-propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[2-(4-Cyano-benzenesulfonylamino)-acetylamino]-3-(3-cyano-phenyl)-propionic acid

There total 3 articles about 2-[2-(4-Cyano-benzenesulfonylamino)-acetylamino]-3-(3-cyano-phenyl)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

(+/-)-3-cyanophenylalanine (63999-80-4) + (4-Cyano-benzenesulfonylamino)-acetic acid 2,5-dioxo-pyrrolidin-1-yl ester (214842-11-2) → 2-[2-(4-Cyano-benzenesulfonylamino)-acetylamino]-3-(3-cyano-phenyl)-propionic acid (214843-45-5)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; for 96h;

DOI:10.1021/jm980227t

Reference yield:

p-cyanobenzenesulfonyl chloride (49584-26-1) → 2-[2-(4-Cyano-benzenesulfonylamino)-acetylamino]-3-(3-cyano-phenyl)-propionic acid (214843-45-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / 1 M NaOH / diethyl ether / 20 h / Ambient temperature

2: 91 percent / DCCl / dioxane / 4 °C

3: 69 percent / Et₃N / dimethylformamide / 96 h

With sodium hydroxide; triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; diethyl ether; N,N-dimethyl-formamide;

DOI:10.1021/jm980227t

Reference yield:

((4-cyanophenyl)sulfonyl)glycine (214841-99-3) → 2-[2-(4-Cyano-benzenesulfonylamino)-acetylamino]-3-(3-cyano-phenyl)-propionic acid (214843-45-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / DCCl / dioxane / 4 °C

2: 69 percent / Et₃N / dimethylformamide / 96 h

With triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1021/jm980227t

upstream raw materials:

(+/-)-3-cyanophenylalanine

(4-Cyano-benzenesulfonylamino)-acetic acid 2,5-dioxo-pyrrolidin-1-yl ester

p-cyanobenzenesulfonyl chloride

((4-cyanophenyl)sulfonyl)glycine

Downstream raw materials:

2-[2-(4-Thiocarbamoyl-benzenesulfonylamino)-acetylamino]-3-(3-thiocarbamoyl-phenyl)-propionic acid