Chemical Property of Amorolfine hydrochloride
Chemical Property:
- Appearance/Colour:white powder
- Vapor Pressure:7.75E-07mmHg at 25°C
- Refractive Index:1.488
- Boiling Point:407.1 °C at 760 mmHg
- Flash Point:119.6 °C
- PSA：12.47000
- Density:1.234
- LogP:5.40190
- Storage Temp.:room temp
- Solubility.:DMSO: ≥5mg/mL (warmed)
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:2
- Rotatable Bond Count:6
- Exact Mass:353.2485425
- Heavy Atom Count:24
- Complexity:336
- Purity/Quality:
-
99% *data from raw suppliers
Amorolfine Hydrochloride *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn
- Hazard Codes:Xn,N
- Statements:
20/21/22-36/37/38-50/53-38-22
- Safety Statements:
26-36-61
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CCC(C)(C)C1=CC=C(C=C1)CC(C)CN2CC(OC(C2)C)C.Cl
- Isomeric SMILES:CCC(C)(C)C1=CC=C(C=C1)CC(C)CN2C[C@H](O[C@H](C2)C)C.Cl
- Recent ClinicalTrials:A Randomized Study to Evaluate the Efficacy of Herbal Ingredients Combined With a Carrier System (Phytonail) Compared With Amorolfine 5% Nail Lacquer (Loceryl) in the Treatment of Toenail Onychomycosis
- Recent EU Clinical Trials:A Randomized, Single-Blinded, Comparative Study of Mycosinate and Curanail in the Treatment of Fungal Nail Infection
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Description
Amorolfine hydrochloride is the first morpholine antifungal agent useful in the topical
treatment of onychomycosis. Mechanistically, it appears to inhibit two stages of the
ergosterol biosynthetic pathway, which is necessary for fungal cell viability. Active
against a broad spectrum of fungi, amorolfiie hydrochloride is particularly effective
against yeasts such as Histoplasma capsulatum, dermatophytes and dematiaceous fungi.
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Uses
Amorolfine hydrochloride has been used as an antifungal agent. antihypertensive
