4-IODOTHIOBENZAMIDE

Base Information

• Chemical Name: 4-IODOTHIOBENZAMIDE
• CAS No.: 106748-23-6
• Molecular Formula: C₇H₆INS
• Molecular Weight: 263.102
• Mol file: 106748-23-6.mol

Synonyms:4-iodobenzothioamide

Chemical Property of 4-IODOTHIOBENZAMIDE

Chemical Property:

• Melting Point: 164～165℃ (dec)

Purity/Quality:

97% ^*data from raw suppliers

4-Iodothiobenzamide 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-IODOTHIOBENZAMIDE

There total 4 articles about 4-IODOTHIOBENZAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4-iodobenzamide (3956-07-8) → 4-iodobenzothioamide (106748-23-6)

Guidance literature:

With Lawessons reagent; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.bmcl.2021.127853

Reference yield: 85.0%

4-iodobenzonitrile (3058-39-7) → 4-iodobenzothioamide (106748-23-6)

Guidance literature:

With 2,3,4,5,7,8,9,10-octahydropyrimido[1,2-a]azepin-1-ium acetate; sodiumsulfide nonahydrate; In neat (no solvent); at 20 ℃; for 2h; Green chemistry;

DOI:10.1039/c7ra11259a

Reference yield:

4-iodobenzoic acid (619-58-9) → 4-iodobenzothioamide (106748-23-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: thionyl chloride / 2 h / Reflux

1.2: 20 °C

2.1: Lawessons reagent / tetrahydrofuran / 20 °C

With Lawessons reagent; thionyl chloride; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2021.127853

upstream raw materials:

4-iodobenzamide

4-iodobenzonitrile

4-iodobenzoic acid

Downstream raw materials:

4-(chloromethyl)-2-(4-iodophenyl)thiazole

4-amino-6-(benzo[d][1,3]dioxol-5-yl)-2-((2-(4-iodophenyl)thiazol-4-yl)methylthio)pyrimidine-5-carbonitrile