Acetic acid 2,6-bis-(2-acetoxy-5-fluoro-benzyl)-4-fluoro-phenyl ester

Base Information

• Chemical Name: Acetic acid 2,6-bis-(2-acetoxy-5-fluoro-benzyl)-4-fluoro-phenyl ester
• CAS No.: 78563-02-7
• Molecular Formula: C₂₆H₂₁F₃O₆
• Molecular Weight: 486.444
• Mol file: 78563-02-7.mol

Synonyms:Acetic acid 2,6-bis-(2-acetoxy-5-fluoro-benzyl)-4-fluoro-phenyl ester

Chemical Property of Acetic acid 2,6-bis-(2-acetoxy-5-fluoro-benzyl)-4-fluoro-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of Acetic acid 2,6-bis-(2-acetoxy-5-fluoro-benzyl)-4-fluoro-phenyl ester

There total 1 articles about Acetic acid 2,6-bis-(2-acetoxy-5-fluoro-benzyl)-4-fluoro-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Fluorophenol (371-41-5) → Acetic acid 2,6-bis-(2-acetoxy-5-fluoro-benzyl)-4-fluoro-phenyl ester (78563-02-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 47 percent / conc. H₂SO₄ / methanol / 6 h / -10 - 5 °C

2: 92 percent / H₂SO₄ / 1 h / Heating

With sulfuric acid; In methanol;

DOI:10.1002/hlca.19810640224

Reference yield: 97.0%

Acetic acid 2,6-bis-(2-acetoxy-5-fluoro-benzyl)-4-fluoro-phenyl ester (78563-02-7) → 1-acetoxy-2,6-bis(2'-acetoxy-5'-fluorobenzoyl)-4-fluorobenzene (78563-15-2)

Guidance literature:

With chromium(VI) oxide; In acetic anhydride; 1.) 2 h, 30 deg C, 2.) 2 h, reflux;

DOI:10.1002/hlca.19810640224

Reference yield: 83.0%

Acetic acid 2,6-bis-(2-acetoxy-5-fluoro-benzyl)-4-fluoro-phenyl ester (78563-02-7) → 1,1′-{[(5-fluoro-2-hydroxy-1,3-phenylene)bis(methylene)]bis(5-fluoro-2-hydroxy-3,1-phenylene)}bis(ethan-1-one)

Guidance literature:

With aluminium trichloride; at 150 - 155 ℃; for 0.333333h;

DOI:10.1002/hlca.19810640224

upstream raw materials:

4-Fluorophenol

Downstream raw materials:

1-acetoxy-2,6-bis(2'-acetoxy-5'-fluorobenzoyl)-4-fluorobenzene

2,6-bis(3-acetyl-5-fluoro-2-hydroxy-benzoyl)-4-fluorophenol

Acetic acid 2,6-bis-(2-acetoxy-3-acetyl-5-fluoro-benzyl)-4-fluoro-phenyl ester