1-((2R,4S,5R)-4-Hydroxy-5-trityloxymethyl-tetrahydro-thiophen-2-yl)-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:1-((2R,4S,5R)-4-Hydroxy-5-trityloxymethyl-tetrahydro-thiophen-2-yl)-1H-pyrimidine-2,4-dione
CAS No.:166812-92-6
Molecular Formula:C₂₈H₂₆N₂O₄S
Molecular Weight:486.591
Hs Code.:

Synonyms:1-((2R,4S,5R)-4-Hydroxy-5-trityloxymethyl-tetrahydro-thiophen-2-yl)-1H-pyrimidine-2,4-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-((2R,4S,5R)-4-Hydroxy-5-trityloxymethyl-tetrahydro-thiophen-2-yl)-1H-pyrimidine-2,4-dione

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-((2R,4S,5R)-4-Hydroxy-5-trityloxymethyl-tetrahydro-thiophen-2-yl)-1H-pyrimidine-2,4-dione

There total 4 articles about 1-((2R,4S,5R)-4-Hydroxy-5-trityloxymethyl-tetrahydro-thiophen-2-yl)-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 134938-97-9
benzyl 3,5-di-O-benzyl-2-deoxy-1,4-dithio-D-erythro-pentofuranoside

: 166812-92-6
1-((2R,4S,5R)-4-Hydroxy-5-trityloxymethyl-tetrahydro-thiophen-2-yl)-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1: 67 percent / acetic acid

2: 82 percent / CF₃SO₃SiMe₃ / 1,2-dichloro-ethane / Ambient temperature

3: 40 percent / pyridine

4: 60 percent / BBr₃ / CH₂Cl₂

5: 66 percent

With pyridine; trimethylsilyl trifluoromethanesulfonate; boron tribromide; In dichloromethane; acetic acid; 1,2-dichloro-ethane;
DOI:10.1016/S0040-4039(00)78345-6

Reference yield:

: 134700-26-8
1-O-acetyl-2-deoxy-3,5-di-O-benzyl-4-thio-D-erythro-pentafuranose

: 166812-92-6
1-((2R,4S,5R)-4-Hydroxy-5-trityloxymethyl-tetrahydro-thiophen-2-yl)-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / CF₃SO₃SiMe₃ / 1,2-dichloro-ethane / Ambient temperature

2: 40 percent / pyridine

3: 60 percent / BBr₃ / CH₂Cl₂

4: 66 percent

With pyridine; trimethylsilyl trifluoromethanesulfonate; boron tribromide; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/S0040-4039(00)78345-6

Reference yield:

: 219613-62-4
1-((4S,5R)-4-Benzyloxy-5-benzyloxymethyl-tetrahydro-thiophen-2-yl)-1H-pyrimidine-2,4-dione

: 166812-92-6
1-((2R,4S,5R)-4-Hydroxy-5-trityloxymethyl-tetrahydro-thiophen-2-yl)-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 40 percent / pyridine

2: 60 percent / BBr₃ / CH₂Cl₂

3: 66 percent

With pyridine; boron tribromide; In dichloromethane;
DOI:10.1016/S0040-4039(00)78345-6