(S)-5-cyclopropyl-4,4-difluoro-2-((S)-2,2,2-trifluoro-1-phenylethylamino)pentanoic acid

Base Information

Chemical Name:(S)-5-cyclopropyl-4,4-difluoro-2-((S)-2,2,2-trifluoro-1-phenylethylamino)pentanoic acid
CAS No.:1084897-86-8
Molecular Formula:C₁₆H₁₈F₅NO₂
Molecular Weight:351.316
Hs Code.:

Synonyms:(S)-5-cyclopropyl-4,4-difluoro-2-((S)-2,2,2-trifluoro-1-phenylethylamino)pentanoic acid

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Chemical Property of (S)-5-cyclopropyl-4,4-difluoro-2-((S)-2,2,2-trifluoro-1-phenylethylamino)pentanoic acid

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Technology Process of (S)-5-cyclopropyl-4,4-difluoro-2-((S)-2,2,2-trifluoro-1-phenylethylamino)pentanoic acid

There total 4 articles about (S)-5-cyclopropyl-4,4-difluoro-2-((S)-2,2,2-trifluoro-1-phenylethylamino)pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.3%

: 1017933-40-2
methyl (S)-2-amino-5-cyclopropyl-4,4-difluoropentanoate hydrochloride

: 434-45-7
2,2,2-Trifluoroacetophenone

: 1084897-86-8
(S)-5-cyclopropyl-4,4-difluoro-2-((S)-2,2,2-trifluoro-1-phenylethylamino)pentanoic acid

Guidance literature:: methyl (S)-2-amino-5-cyclopropyl-4,4-difluoropentanoate hydrochloride; 2,2,2-Trifluoroacetophenone; With potassium carbonate; In isopropyl alcohol; at 60 ℃; for 20h; Inert atmosphere;

With methanol; zinc(II) tetrahydroborate; In acetonitrile; at -45 ℃; for 1h;

Reference yield:

: 1017933-24-2
(2S)-2-benzyloxycarbonylamino-4-oxo-5-cyclopropylpentanoic acid methyl ester

: 1084897-86-8
(S)-5-cyclopropyl-4,4-difluoro-2-((S)-2,2,2-trifluoro-1-phenylethylamino)pentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: diethylamino-sulfur trifluoride / 48 h / 20 °C / sealed tube

2.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

3.1: potassium carbonate / isopropyl alcohol / 20 h / 60 °C / Inert atmosphere

3.2: 1 h / -45 °C

With hydrogenchloride; diethylamino-sulfur trifluoride; potassium carbonate; In 1,4-dioxane; isopropyl alcohol;

Reference yield:

: 1017933-32-2
(2S)-2-benzyloxycarbonylamino-4,4-difluoro-5-cyclopropylpentanoic acid methyl ester

: 1084897-86-8
(S)-5-cyclopropyl-4,4-difluoro-2-((S)-2,2,2-trifluoro-1-phenylethylamino)pentanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

2.1: potassium carbonate / isopropyl alcohol / 20 h / 60 °C / Inert atmosphere

2.2: 1 h / -45 °C

With hydrogenchloride; potassium carbonate; In 1,4-dioxane; isopropyl alcohol;