Methyl-carbamic acid 5-methylcarbamoyloxymethyl-3-phenyl-3H-imidazol-4-ylmethyl ester

Base Information

• Chemical Name: Methyl-carbamic acid 5-methylcarbamoyloxymethyl-3-phenyl-3H-imidazol-4-ylmethyl ester
• CAS No.: 117120-84-0
• Molecular Formula: C₁₅H₁₈N₄O₄
• Molecular Weight: 318.332
• Mol file: 117120-84-0.mol

Synonyms:Methyl-carbamic acid 5-methylcarbamoyloxymethyl-3-phenyl-3H-imidazol-4-ylmethyl ester

Chemical Property of Methyl-carbamic acid 5-methylcarbamoyloxymethyl-3-phenyl-3H-imidazol-4-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl-carbamic acid 5-methylcarbamoyloxymethyl-3-phenyl-3H-imidazol-4-ylmethyl ester

There total 3 articles about Methyl-carbamic acid 5-methylcarbamoyloxymethyl-3-phenyl-3H-imidazol-4-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

methyl isocyanate (624-83-9) + (1-phenyl-1H-imidazole-4,5-diyl)-bis-methanol (33457-06-6) → Methyl-carbamic acid 5-methylcarbamoyloxymethyl-3-phenyl-3H-imidazol-4-ylmethyl ester (117120-84-0)

Guidance literature:

With pyridine; In dichloromethane; for 24h; Ambient temperature;

DOI:10.1021/jm00121a023

Reference yield:

diethyl 1-phenyl-1H-imidazole-4,5-dicarboxylate (117121-01-4) → Methyl-carbamic acid 5-methylcarbamoyloxymethyl-3-phenyl-3H-imidazol-4-ylmethyl ester (117120-84-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / LiAlH₄ / CH₂Cl₂; diethyl ether / a) 0 - 5 deg C, 3 h, b) room temperature, 1 h

2: 38 percent / pyridine / CH₂Cl₂ / 24 h / Ambient temperature

With pyridine; lithium aluminium tetrahydride; In diethyl ether; dichloromethane;

DOI:10.1021/jm00121a023

Reference yield:

diethyl 2-mercapto-1-phenylimidazole-4,5-dicarboxylate (117121-07-0) → Methyl-carbamic acid 5-methylcarbamoyloxymethyl-3-phenyl-3H-imidazol-4-ylmethyl ester (117120-84-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / conc. nitric acid, sodium nitrite / H₂O / 1 h / 33 - 38 °C

2: 65 percent / LiAlH₄ / CH₂Cl₂; diethyl ether / a) 0 - 5 deg C, 3 h, b) room temperature, 1 h

3: 38 percent / pyridine / CH₂Cl₂ / 24 h / Ambient temperature

With pyridine; lithium aluminium tetrahydride; nitric acid; sodium nitrite; In diethyl ether; dichloromethane; water;

DOI:10.1021/jm00121a023

upstream raw materials:

methyl isocyanate

(1-phenyl-1H-imidazole-4,5-diyl)-bis-methanol

diethyl 1-phenyl-1H-imidazole-4,5-dicarboxylate

diethyl 2-mercapto-1-phenylimidazole-4,5-dicarboxylate