N₅-(3-(9H-purin-6-yl)pyridin-2-yl)-N₁-((R)-1-(4-chlorophenyl)ethyl)-6-methylisoquinoline-1,5-diamine

Base Information

• Chemical Name: N₅-(3-(9H-purin-6-yl)pyridin-2-yl)-N₁-((R)-1-(4-chlorophenyl)ethyl)-6-methylisoquinoline-1,5-diamine
• CAS No.: 1093100-63-0
• Molecular Formula: C₂₈H₂₃ClN₈
• Molecular Weight: 506.997
• Mol file: 1093100-63-0.mol

Synonyms:N₅-(3-(9H-purin-6-yl)pyridin-2-yl)-N₁-((R)-1-(4-chlorophenyl)ethyl)-6-methylisoquinoline-1,5-diamine

Chemical Property of N₅-(3-(9H-purin-6-yl)pyridin-2-yl)-N₁-((R)-1-(4-chlorophenyl)ethyl)-6-methylisoquinoline-1,5-diamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₅-(3-(9H-purin-6-yl)pyridin-2-yl)-N₁-((R)-1-(4-chlorophenyl)ethyl)-6-methylisoquinoline-1,5-diamine

There total 10 articles about N₅-(3-(9H-purin-6-yl)pyridin-2-yl)-N₁-((R)-1-(4-chlorophenyl)ethyl)-6-methylisoquinoline-1,5-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N1-((R)-1-(4-chlorophenyl)ethyl)-6-methyl-N5-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-yl)isoquinoline-1,5-diamine (1093101-70-2) → N5-(3-(9H-purin-6-yl)pyridin-2-yl)-N1-((R)-1-(4-chlorophenyl)ethyl)-6-methylisoquinoline-1,5-diamine (1093100-63-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 100 ℃; for 3h;

Reference yield:

6-chloropurine (87-42-3) → N5-(3-(9H-purin-6-yl)pyridin-2-yl)-N1-((R)-1-(4-chlorophenyl)ethyl)-6-methylisoquinoline-1,5-diamine (1093100-63-0)

Guidance literature:

Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid / ethyl acetate / 1 h / 90 °C

2: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 10 h / 100 °C

3: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / 0 °C

4: hydrogenchloride / 1,4-dioxane / 3 h / 100 °C

With hydrogenchloride; sodium carbonate; toluene-4-sulfonic acid; lithium hexamethyldisilazane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; water; ethyl acetate; 2: Suzuki Coupling;

Reference yield:

6-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine (7306-68-5) → N5-(3-(9H-purin-6-yl)pyridin-2-yl)-N1-((R)-1-(4-chlorophenyl)ethyl)-6-methylisoquinoline-1,5-diamine (1093100-63-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 10 h / 100 °C

2: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / 0 °C

3: hydrogenchloride / 1,4-dioxane / 3 h / 100 °C

With hydrogenchloride; sodium carbonate; lithium hexamethyldisilazane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; water; 1: Suzuki Coupling;

upstream raw materials:

N₁-((R)-1-(4-chlorophenyl)ethyl)-6-methyl-N₅-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-yl)isoquinoline-1,5-diamine

6-methyl-5-nitroisoquinoline

6-methylisoquinoline

1-chloro-6-methyl-5-nitroisoquinoline

Refernces