(2R,3S,4S)-5-Acetoxy-4-benzoyloxy-3-fluoro-tetrahydro-furan-2-carboxylic acid methyl ester

Base Information

Chemical Name:(2R,3S,4S)-5-Acetoxy-4-benzoyloxy-3-fluoro-tetrahydro-furan-2-carboxylic acid methyl ester
CAS No.:551929-65-8
Molecular Formula:C₁₅H₁₅FO₇
Molecular Weight:326.278
Hs Code.:

Synonyms:(2R,3S,4S)-5-Acetoxy-4-benzoyloxy-3-fluoro-tetrahydro-furan-2-carboxylic acid methyl ester

Suppliers and Price of (2R,3S,4S)-5-Acetoxy-4-benzoyloxy-3-fluoro-tetrahydro-furan-2-carboxylic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,3S,4S)-5-Acetoxy-4-benzoyloxy-3-fluoro-tetrahydro-furan-2-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,3S,4S)-5-Acetoxy-4-benzoyloxy-3-fluoro-tetrahydro-furan-2-carboxylic acid methyl ester

There total 14 articles about (2R,3S,4S)-5-Acetoxy-4-benzoyloxy-3-fluoro-tetrahydro-furan-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 108-24-7
acetic anhydride

: 551929-64-7
(2R,3S,4S,5R)-4-Benzoyloxy-3-fluoro-5-methoxy-tetrahydro-furan-2-carboxylic acid methyl ester

: 551929-65-8
(2R,3S,4S)-5-Acetoxy-4-benzoyloxy-3-fluoro-tetrahydro-furan-2-carboxylic acid methyl ester

Guidance literature:: With sulfuric acid; acetic acid; at 0 - 20 ℃; for 0.5h;
DOI:10.1016/S0960-894X(03)00027-1

Reference yield:

: 152711-00-7
Methyl 3-deoxy-3-fluoro-β-D-arabinofuranoside

: 551929-65-8
(2R,3S,4S)-5-Acetoxy-4-benzoyloxy-3-fluoro-tetrahydro-furan-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: pyridine

2: 52 percent / 18-crown-6 / dimethylsulfoxide / Heating

3: MeONa

4: RuCl₃; NaIO₄ / acetonitrile; CCl₄; H₂O

5: DCC; DMAP

6: TBAF; AcOH / tetrahydrofuran

7: 83 percent / AcOH; H₂SO₄

With pyridine; dmap; ruthenium trichloride; sodium periodate; 18-crown-6 ether; sulfuric acid; tetrabutyl ammonium fluoride; sodium methylate; acetic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; tetrachloromethane; water; dimethyl sulfoxide; acetonitrile;
DOI:10.1081/NCN-120022701

Reference yield:

: 237410-10-5
((2R,3S,4S,5R)-3-fluoro-4-hydroxy-5-methoxytetrahydrofuran-2-yl)methyl benzoate

: 551929-65-8
(2R,3S,4S)-5-Acetoxy-4-benzoyloxy-3-fluoro-tetrahydro-furan-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: MeONa

2: RuCl₃; NaIO₄ / acetonitrile; CCl₄; H₂O

3: DCC; DMAP

4: TBAF; AcOH / tetrahydrofuran

5: 83 percent / AcOH; H₂SO₄

With dmap; ruthenium trichloride; sodium periodate; sulfuric acid; tetrabutyl ammonium fluoride; sodium methylate; acetic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; tetrachloromethane; water; acetonitrile;
DOI:10.1081/NCN-120022701