7-(4-Fluoro-phenyl)-7-(6-hydroxy-4,7-dimethyl-3-oxo-indan-5-yl)-heptanoic acid

Base Information

Chemical Name:7-(4-Fluoro-phenyl)-7-(6-hydroxy-4,7-dimethyl-3-oxo-indan-5-yl)-heptanoic acid
CAS No.:121100-01-4
Molecular Formula:C₂₄H₂₇FO₄
Molecular Weight:398.474
Hs Code.:

Synonyms:7-(4-Fluoro-phenyl)-7-(6-hydroxy-4,7-dimethyl-3-oxo-indan-5-yl)-heptanoic acid

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Chemical Property of 7-(4-Fluoro-phenyl)-7-(6-hydroxy-4,7-dimethyl-3-oxo-indan-5-yl)-heptanoic acid

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Technology Process of 7-(4-Fluoro-phenyl)-7-(6-hydroxy-4,7-dimethyl-3-oxo-indan-5-yl)-heptanoic acid

There total 6 articles about 7-(4-Fluoro-phenyl)-7-(6-hydroxy-4,7-dimethyl-3-oxo-indan-5-yl)-heptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 7-(4-Fluoro-phenyl)-7-(6-hydroxy-4,7-dimethyl-3-oxo-indan-5-yl)-heptanoic acid methyl ester

: 121100-01-4
7-(4-Fluoro-phenyl)-7-(6-hydroxy-4,7-dimethyl-3-oxo-indan-5-yl)-heptanoic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; for 13h; Ambient temperature;
DOI:10.1021/jm00090a009

Reference yield:

: 57122-11-9
6-methoxy-4,7-dimethyl-2,3-dihydro-1H-inden-1-one

: 121100-01-4
7-(4-Fluoro-phenyl)-7-(6-hydroxy-4,7-dimethyl-3-oxo-indan-5-yl)-heptanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 99 percent / NaBH₄ / methanol; tetrahydrofuran / 1 h / Ambient temperature

2: 96 percent / H₂ / palladium black / acetic acid / 3 h / Ambient temperature

3: 99 percent / BBr₃ / CH₂Cl₂ / 1 h / Ambient temperature

4: BF₃*Et₂O / 1,2-dichloro-ethane / 6 h / 60 °C

5: PCC, Celite / benzene / 2 h

6: 25 percent / 1 N NaOH / tetrahydrofuran / 13 h / Ambient temperature

With sodium hydroxide; sodium tetrahydroborate; Celite; boron trifluoride diethyl etherate; hydrogen; boron tribromide; pyridinium chlorochromate; palladium; In tetrahydrofuran; methanol; dichloromethane; acetic acid; 1,2-dichloro-ethane; benzene;
DOI:10.1021/jm00090a009

Reference yield:

: 140875-09-8
6-methoxy-4,7-dimethyl-1-indanol

: 121100-01-4
7-(4-Fluoro-phenyl)-7-(6-hydroxy-4,7-dimethyl-3-oxo-indan-5-yl)-heptanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / H₂ / palladium black / acetic acid / 3 h / Ambient temperature

2: 99 percent / BBr₃ / CH₂Cl₂ / 1 h / Ambient temperature

3: BF₃*Et₂O / 1,2-dichloro-ethane / 6 h / 60 °C

4: PCC, Celite / benzene / 2 h

5: 25 percent / 1 N NaOH / tetrahydrofuran / 13 h / Ambient temperature

With sodium hydroxide; Celite; boron trifluoride diethyl etherate; hydrogen; boron tribromide; pyridinium chlorochromate; palladium; In tetrahydrofuran; dichloromethane; acetic acid; 1,2-dichloro-ethane; benzene;
DOI:10.1021/jm00090a009