F 14679

Base Information

• Chemical Name: F 14679
• CAS No.: 208109-38-0
• Molecular Formula: C₂₁H₂₅ClF₂N₄O
• Molecular Weight: 422.906

Synonyms:F 14679

Chemical Property of F 14679

Chemical Property:

Purity/Quality:

98%+ ^*data from raw suppliers

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Technology Process of F 14679

There total 16 articles about F 14679 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-[1-[(3-chloro-4-fluorophenyl)carbonyl]-4-fluoropiperidin-4-yl]-2-hydroxyacetonitrile (448920-98-7) + (6-methyl-amino-5-methylpyridin-2-yl)methylamine (448920-96-5) → F 14679 (208109-38-0)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; sodium cyanoborohydride; iron(II) sulfate; In methanol; at 20 ℃; for 4h;

Reference yield: 55.6%

→ F 14679 (208109-38-0)

Guidance literature:

Reference yield:

(3-Chloro-4-fluoro-phenyl)-[4-fluoro-4-({[1-(5-methyl-6-methylamino-pyridin-2-yl)-meth-(E)-ylidene]-amino}-methyl)-piperidin-1-yl]-methanone → F 14679 (208109-38-0)

Guidance literature:

With potassium borohydride; In methanol; for 18h; Yield given; Ambient temperature;

DOI:10.1021/jm9806906

upstream raw materials:

4,4-ethylenedioxy-piperidine

3-chloro-4-fluorobenzoyl chloride

5-methyl-6-chloro-2-pyridinecarboxylic acid ethyl ester

5-methyl-6-chloro-2-pyridinemethanol

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