2-AMINO-5-BROMO-3-METHOXYBENZOIC ACID

Base Information

• Chemical Name: 2-AMINO-5-BROMO-3-METHOXYBENZOIC ACID
• CAS No.: 864293-44-7
• Molecular Formula: C₈H₈BrNO₃
• Molecular Weight: 246.06
• Hs Code.: 2916399090
• Mol file: 864293-44-7.mol

Synonyms:2-amino-5-bromo-3-methoxy benzoic acid

Chemical Property of 2-AMINO-5-BROMO-3-METHOXYBENZOIC ACID

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 356.0±42.0 °C(Predicted)
• PKA: 4.43±0.10(Predicted)
• Density: 1.703±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

2-Amino-5-bromo-3-methoxybenzoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-5-BROMO-3-METHOXYBENZOIC ACID

There total 6 articles about 2-AMINO-5-BROMO-3-METHOXYBENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-amino-3-methoxybenzoic acid (3177-80-8) → 2-amino-5-bromo-3-methoxy benzoic acid (864293-44-7)

Guidance literature:

With N-Bromosuccinimide; In methanol; at -5 - 0 ℃;

Reference yield: 83.3%

5-bromo-7-methoxyindoline-2,3-dione → 2-amino-5-bromo-3-methoxy benzoic acid (864293-44-7)

Guidance literature:

With dihydrogen peroxide; sodium hydroxide; at 60 ℃; for 1h; Temperature;

Reference yield:

4-bromo-2-fluoronitrobenzene (321-23-3) → 2-amino-5-bromo-3-methoxy benzoic acid (864293-44-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 3 h / 60 °C

2.1: acetic acid; iron / ethanol; water / 6 h / 80 °C

3.1: sodium sulfate; hydrogenchloride / water; 1,4-dioxane / 0.17 h / 50 °C

3.2: 6 h / 80 °C

4.1: sulfuric acid / 1 h / 40 °C

5.1: sodium hydroxide; dihydrogen peroxide / 1 h / 60 °C

With hydrogenchloride; sulfuric acid; dihydrogen peroxide; iron; acetic acid; sodium sulfate; sodium hydroxide; In 1,4-dioxane; ethanol; water;

upstream raw materials:

2-amino-3-methoxybenzoic acid

4-bromo-2-fluoronitrobenzene

4-bromo-2-methoxy-1-nitro-benzene

4-bromo-2-methoxyaniline

Downstream raw materials:

3-bromo-5-methoxybenzoic acid

Refernces

• 1、 -. "Preparation method of 2-amino-3-methoxy-5-bromobenzonitrile". . . Retrieved 2021/02/10.
• 2、 Lin, Songwen,Wang, Chunyang,Ji, Ming,Wu, Deyu,Lv, Yuanhao,Zhang, Kehui,Dong, Yi,Jin, Jing,Chen, Jiajing,Zhang, Jingbo,Sheng, Li,Li, Yan,Chen, Xiaoguang,Xu, Heng. "Discovery and Optimization of 2-Amino-4-methylquinazoline Derivatives as Highly Potent Phosphatidylinositol 3-Kinase Inhibitors for Cancer Treatment". . p. 6087 - 6109. Retrieved 2018/07/05.