[(E)-(R)-3-[4-[(E)-(R)-3-Benzyloxycarbonylamino-4-(2-trimethylsilanyl-ethoxymethoxy)-but-1-enyl]-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrol-3-yl]-1-(2-trimethylsilanyl-ethoxymethoxymethyl)-allyl]-carbamic acid benzyl ester

Base Information

• Chemical Name: [(E)-(R)-3-[4-[(E)-(R)-3-Benzyloxycarbonylamino-4-(2-trimethylsilanyl-ethoxymethoxy)-but-1-enyl]-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrol-3-yl]-1-(2-trimethylsilanyl-ethoxymethoxymethyl)-allyl]-carbamic acid benzyl ester
• CAS No.: 444993-51-5
• Molecular Formula: C₄₆H₇₃N₃O₉Si₃
• Molecular Weight: 896.357

Synonyms:[(E)-(R)-3-[4-[(E)-(R)-3-Benzyloxycarbonylamino-4-(2-trimethylsilanyl-ethoxymethoxy)-but-1-enyl]-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrol-3-yl]-1-(2-trimethylsilanyl-ethoxymethoxymethyl)-allyl]-carbamic acid benzyl ester

Chemical Property of [(E)-(R)-3-[4-[(E)-(R)-3-Benzyloxycarbonylamino-4-(2-trimethylsilanyl-ethoxymethoxy)-but-1-enyl]-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrol-3-yl]-1-(2-trimethylsilanyl-ethoxymethoxymethyl)-allyl]-carbamic acid benzyl ester

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Technology Process of [(E)-(R)-3-[4-[(E)-(R)-3-Benzyloxycarbonylamino-4-(2-trimethylsilanyl-ethoxymethoxy)-but-1-enyl]-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrol-3-yl]-1-(2-trimethylsilanyl-ethoxymethoxymethyl)-allyl]-carbamic acid benzyl ester

There total 4 articles about [(E)-(R)-3-[4-[(E)-(R)-3-Benzyloxycarbonylamino-4-(2-trimethylsilanyl-ethoxymethoxy)-but-1-enyl]-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrol-3-yl]-1-(2-trimethylsilanyl-ethoxymethoxymethyl)-allyl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

3,4-diiodo-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrole (444993-47-9) + [(R)-1-(2-Trimethylsilanyl-ethoxymethoxymethyl)-allyl]-carbamic acid benzyl ester (444993-46-8) → [(E)-(R)-3-[4-[(E)-(R)-3-Benzyloxycarbonylamino-4-(2-trimethylsilanyl-ethoxymethoxy)-but-1-enyl]-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrol-3-yl]-1-(2-trimethylsilanyl-ethoxymethoxymethyl)-allyl]-carbamic acid benzyl ester (444993-51-5)

Guidance literature:

With tributylphosphine; potassium carbonate; palladium diacetate; In N,N-dimethyl-formamide; at 100 ℃;

DOI:10.1016/S0040-4039(02)00512-9

Reference yield:

(2-trimethylethylsilylethoxy)methyl chloride (76513-69-4) → [(E)-(R)-3-[4-[(E)-(R)-3-Benzyloxycarbonylamino-4-(2-trimethylsilanyl-ethoxymethoxy)-but-1-enyl]-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrol-3-yl]-1-(2-trimethylsilanyl-ethoxymethoxymethyl)-allyl]-carbamic acid benzyl ester (444993-51-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / DIPEA

2: 33 percent / K₂CO₃; n-Bu₃P / Pd(OAc)2 / dimethylformamide / 100 °C

With tributylphosphine; potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium diacetate; In N,N-dimethyl-formamide; 2: Heck coupling reaction;

DOI:10.1016/S0040-4039(02)00512-9

Reference yield:

(R)-(1-hydroxymethallyl)carbamic acid benzyl ester (91103-38-7) → [(E)-(R)-3-[4-[(E)-(R)-3-Benzyloxycarbonylamino-4-(2-trimethylsilanyl-ethoxymethoxy)-but-1-enyl]-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrol-3-yl]-1-(2-trimethylsilanyl-ethoxymethoxymethyl)-allyl]-carbamic acid benzyl ester (444993-51-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / DIPEA

2: 33 percent / K₂CO₃; n-Bu₃P / Pd(OAc)2 / dimethylformamide / 100 °C

With tributylphosphine; potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium diacetate; In N,N-dimethyl-formamide; 2: Heck coupling reaction;

DOI:10.1016/S0040-4039(02)00512-9

upstream raw materials:

3,4-diiodo-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrole

[(R)-1-(2-Trimethylsilanyl-ethoxymethoxymethyl)-allyl]-carbamic acid benzyl ester

(2-trimethylethylsilylethoxy)methyl chloride

(R)-(1-hydroxymethallyl)carbamic acid benzyl ester

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