(E)-3-methyl-1-[3,5-bis(trifluoromethyl)phenyldimethylsilyl]-5-(tetrahydropyran-2-yloxy)pent-3-en-1-yne

Base Information

Chemical Name:(E)-3-methyl-1-[3,5-bis(trifluoromethyl)phenyldimethylsilyl]-5-(tetrahydropyran-2-yloxy)pent-3-en-1-yne
CAS No.:1380003-52-0
Molecular Formula:C₂₁H₂₄F₆O₂Si
Molecular Weight:450.496
Hs Code.:

Synonyms:(E)-3-methyl-1-[3,5-bis(trifluoromethyl)phenyldimethylsilyl]-5-(tetrahydropyran-2-yloxy)pent-3-en-1-yne

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Chemical Property of (E)-3-methyl-1-[3,5-bis(trifluoromethyl)phenyldimethylsilyl]-5-(tetrahydropyran-2-yloxy)pent-3-en-1-yne

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Technology Process of (E)-3-methyl-1-[3,5-bis(trifluoromethyl)phenyldimethylsilyl]-5-(tetrahydropyran-2-yloxy)pent-3-en-1-yne

There total 1 articles about (E)-3-methyl-1-[3,5-bis(trifluoromethyl)phenyldimethylsilyl]-5-(tetrahydropyran-2-yloxy)pent-3-en-1-yne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 41967-81-1,58389-95-0,61568-79-4,134079-53-1
(E)-tetrahydro-2-<(3-methyl-2-penten-4-ynyl)oxy>-2H-pyran

: 732306-23-9
chlorodimethyl[3,5-bis(trifluoromethyl)phenyl]silane

: 1380003-52-0
(E)-3-methyl-1-[3,5-bis(trifluoromethyl)phenyldimethylsilyl]-5-(tetrahydropyran-2-yloxy)pent-3-en-1-yne

Guidance literature:: (E)-tetrahydro-2-<(3-methyl-2-penten-4-ynyl)oxy>-2H-pyran; With n-butyllithium; In hexanes; diethyl ether; at -78 ℃; for 1.16667h; Inert atmosphere;

chlorodimethyl[3,5-bis(trifluoromethyl)phenyl]silane; In hexanes; diethyl ether; at -78 - 20 ℃; for 4h; Inert atmosphere;
DOI:10.1002/chem.201103360

Reference yield: 60.0%

: 1380003-52-0
(E)-3-methyl-1-[3,5-bis(trifluoromethyl)phenyldimethylsilyl]-5-(tetrahydropyran-2-yloxy)pent-3-en-1-yne

: 1380003-68-8
(1Z,3E)-3-methyl-1-[3,5-bis(trifluoromethyl)phenyldimethylsilyl]-5-(tetrahydropyran-2-yloxy)pent-1,3-diene

Guidance literature:: (E)-3-methyl-1-[3,5-bis(trifluoromethyl)phenyldimethylsilyl]-5-(tetrahydropyran-2-yloxy)pent-3-en-1-yne; With Schwartz's reagent; In tetrahydrofuran; for 4h; Inert atmosphere;

With pentane; In tetrahydrofuran; for 0.333333h; stereoselective reaction; Inert atmosphere;
DOI:10.1002/chem.201103360

Reference yield:

: 1380003-52-0
(E)-3-methyl-1-[3,5-bis(trifluoromethyl)phenyldimethylsilyl]-5-(tetrahydropyran-2-yloxy)pent-3-en-1-yne

: 1096538-06-5
11-cis-tetrahydropyran-2-yl retinyl ether

Guidance literature:: Multi-step reaction with 2 steps

1.1: Schwartz's reagent / tetrahydrofuran / 4 h / Inert atmosphere

1.2: 0.33 h / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere; Darkness

2.2: 1 h / 20 °C / Inert atmosphere; Darkness

With Schwartz's reagent; tetrabutyl ammonium fluoride; In tetrahydrofuran; 2.1: Hiyama coupling / 2.2: Hiyama coupling;
DOI:10.1002/chem.201103360