α-(2,6-dimethoxyphenyl)vinyl chloride

Base Information

• Chemical Name: α-(2,6-dimethoxyphenyl)vinyl chloride
• CAS No.: 132338-43-3
• Molecular Formula: C₁₀H₁₁ClO₂
• Molecular Weight: 198.649
• Mol file: 132338-43-3.mol

Synonyms:α-(2,6-dimethoxyphenyl)vinyl chloride

Chemical Property of α-(2,6-dimethoxyphenyl)vinyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α-(2,6-dimethoxyphenyl)vinyl chloride

There total 2 articles about α-(2,6-dimethoxyphenyl)vinyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-ethynyl-2,6-dimethoxybenzene (126829-31-0) → α-(2,6-dimethoxyphenyl)vinyl chloride (132338-43-3)

Guidance literature:

1-ethynyl-2,6-dimethoxybenzene; With acetic anhydride; In nitromethane; at 20 ℃; for 0.5h; Inert atmosphere;

With hydrogenchloride; In nitromethane; at 20 ℃; for 3h; under 760.051 Torr; regioselective reaction;

DOI:10.1016/j.cclet.2016.04.019

Reference yield: 72.3%

2,6-dimethoxyacetophenone (2040-04-2) → α-(2,6-dimethoxyphenyl)vinyl chloride (132338-43-3)

Guidance literature:

With phosphorus pentachloride; phosphorus trichloride; In benzene; Ambient temperature;

DOI:10.1016/S0040-4039(00)97162-4

Reference yield: 79.6%

α-(2,6-dimethoxyphenyl)vinyl chloride (132338-43-3) → 1-ethynyl-2,6-dimethoxybenzene (126829-31-0)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; hexane; for 5h; -78 deg C to r.t.;

DOI:10.1016/S0040-4039(00)97162-4

upstream raw materials:

2,6-dimethoxyacetophenone

1-ethynyl-2,6-dimethoxybenzene

Downstream raw materials:

1-ethynyl-2,6-dimethoxybenzene

methyl 2-<(2,6-dimethoxyphenyl)ethynyl>benzoate

2,4-bis(2,6-dimethoxyphenyl)but-1-en-3-yne

methyl 2-<(2,6-dimethoxyphenyl)ethynyl>-3-methoxybenzoate

Refernces

• 1、 Evans, Kevin L.,Prince, Philippe,Huang, Enoch T.,Boss, Keisha R.,Gandour, Richard D.. "MOLECULES FOR INTRAMOLECULAR RECOGNITION. SYNTHESIS AND STRUCTURES OF DIARYL- AND ARYLNAPHTHYLETHYNES". . p. 6753 - 6756. Retrieved 2007/10/02.