(Rs)-N-[(S)-2,2-difluoro-1-phenyl-2-(phenylthio)ethyl]-2-methylpropane-2-sulfinamide

Base Information

Chemical Name:(Rs)-N-[(S)-2,2-difluoro-1-phenyl-2-(phenylthio)ethyl]-2-methylpropane-2-sulfinamide
CAS No.:938463-78-6
Molecular Formula:C₁₈H₂₁F₂NOS₂
Molecular Weight:369.5
Hs Code.:

Synonyms:(Rs)-N-[(S)-2,2-difluoro-1-phenyl-2-(phenylthio)ethyl]-2-methylpropane-2-sulfinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Rs)-N-[(S)-2,2-difluoro-1-phenyl-2-(phenylthio)ethyl]-2-methylpropane-2-sulfinamide

Chemical Property:

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Technology Process of (Rs)-N-[(S)-2,2-difluoro-1-phenyl-2-(phenylthio)ethyl]-2-methylpropane-2-sulfinamide

There total 1 articles about (Rs)-N-[(S)-2,2-difluoro-1-phenyl-2-(phenylthio)ethyl]-2-methylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 196929-85-8
(R)-N-benzylidene-2-methylpropane-2-sulfinamide

: 1535-67-7
difluoromethyl phenyl sulfide

: 938463-78-6
(Rs)-N-[(S)-2,2-difluoro-1-phenyl-2-(phenylthio)ethyl]-2-methylpropane-2-sulfinamide

: (Rs)-N-[(R)-2,2-difluoro-1-phenyl-2-(phenylthio)ethyl]-2-methylpropane-2-sulfinamide

Guidance literature:: With potassium tert-butylate; In N,N-dimethyl-formamide; at -40 - -30 ℃; for 2h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1016/j.jfluchem.2011.08.007

Reference yield:

: 938463-78-6
(Rs)-N-[(S)-2,2-difluoro-1-phenyl-2-(phenylthio)ethyl]-2-methylpropane-2-sulfinamide

: C₁₄H₁₃F₂NS

Guidance literature:: With hydrogenchloride; methanol; In 1,4-dioxane; at 20 ℃; for 1h;
DOI:10.1002/anie.200604783

Reference yield:

: 938463-78-6
(Rs)-N-[(S)-2,2-difluoro-1-phenyl-2-(phenylthio)ethyl]-2-methylpropane-2-sulfinamide

: 938463-88-8
C₁₇H₁₇F₂NS

Guidance literature:: Multi-step reaction with 2 steps

1: HCl / dioxane; methanol / 1 h / 20 °C

2: 285 mg / K₂CO₃ / dimethylformamide / 20 °C

With hydrogenchloride; potassium carbonate; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1002/anie.200604783