4-(3-{2-[(S)-2-Hydroxy-3-(2-trimethylsilanyl-phenoxy)-propylamino]-ethyl}-ureido)-benzoic acid methyl ester

Base Information

Chemical Name:4-(3-{2-[(S)-2-Hydroxy-3-(2-trimethylsilanyl-phenoxy)-propylamino]-ethyl}-ureido)-benzoic acid methyl ester
CAS No.:769167-42-2
Molecular Formula:C₂₃H₃₃N₃O₅Si
Molecular Weight:459.618
Hs Code.:

Synonyms:4-(3-{2-[(S)-2-Hydroxy-3-(2-trimethylsilanyl-phenoxy)-propylamino]-ethyl}-ureido)-benzoic acid methyl ester

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Chemical Property of 4-(3-{2-[(S)-2-Hydroxy-3-(2-trimethylsilanyl-phenoxy)-propylamino]-ethyl}-ureido)-benzoic acid methyl ester

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Technology Process of 4-(3-{2-[(S)-2-Hydroxy-3-(2-trimethylsilanyl-phenoxy)-propylamino]-ethyl}-ureido)-benzoic acid methyl ester

There total 4 articles about 4-(3-{2-[(S)-2-Hydroxy-3-(2-trimethylsilanyl-phenoxy)-propylamino]-ethyl}-ureido)-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 769167-37-5
(S)-2-(2-trimethylsilylphenoxymethyl)oxirane

: 769167-40-0
N-(2-amino-ethyl)-N'-(4-methoxycarbonyl-phenyl)urea

: 769167-42-2
4-(3-{2-[(S)-2-Hydroxy-3-(2-trimethylsilanyl-phenoxy)-propylamino]-ethyl}-ureido)-benzoic acid methyl ester

Guidance literature:: In acetonitrile; Heating;
DOI:10.1016/j.bmc.2004.05.027

Reference yield:

: 15288-53-6
o-(trimethylsilyl)phenol

: 769167-42-2
4-(3-{2-[(S)-2-Hydroxy-3-(2-trimethylsilanyl-phenoxy)-propylamino]-ethyl}-ureido)-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / K₂CO₃ / butan-2-one / Heating

2: 35 percent / acetonitrile / Heating

With potassium carbonate; In acetonitrile; butanone;
DOI:10.1016/j.bmc.2004.05.027

Reference yield:

: 23138-53-6
methyl 4-isocyanatobenzoate

: 769167-42-2
4-(3-{2-[(S)-2-Hydroxy-3-(2-trimethylsilanyl-phenoxy)-propylamino]-ethyl}-ureido)-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / diethyl ether / 13 h / 4 °C

2: HCl / methanol / 1.5 h / 50 °C

3: 35 percent / acetonitrile / Heating

With hydrogenchloride; In methanol; diethyl ether; acetonitrile;
DOI:10.1016/j.bmc.2004.05.027