Technology Process of 3,4-dihydroxy-5-(trifluoromethyl)benzoic acid
There total 5 articles about 3,4-dihydroxy-5-(trifluoromethyl)benzoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-hydroxy-3-methoxy-5-(trifluoromethyl)benzoic acid;
With
boron tribromide;
In
dichloromethane;
at 0 - 20 ℃;
for 70h;
With
water;
In
dichloromethane;
for 0.166667h;
Cooling with ice bath;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium / tetrahydrofuran / -78 °C
1.2: -78 - 20 °C
2.1: formic acid; dihydrogen peroxide / water / 2 h / 0 - 20 °C
3.1: trifluoroacetic acid; hexamethylenetetramine / 3 h / Reflux
4.1: Oxone / N,N-dimethyl-formamide / 2 h / 20 °C
5.1: boron tribromide / dichloromethane / 70 h / 0 - 20 °C
5.2: 0.17 h / Cooling with ice bath
With
Oxone; formic acid; N,N,N,N,-tetramethylethylenediamine; hexamethylenetetramine; dihydrogen peroxide; sec.-butyllithium; boron tribromide; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: Oxone / N,N-dimethyl-formamide / 2 h / 20 °C
2.1: boron tribromide / dichloromethane / 70 h / 0 - 20 °C
2.2: 0.17 h / Cooling with ice bath
With
Oxone; boron tribromide;
In
dichloromethane; N,N-dimethyl-formamide;
