tert-butyl (2-((4-((4-fluorobenzyl)amino)-6-(prop-2-yn-1-ylamino)-1,3,5-triazin-2-yl)amino)ethyl)carbamate

Base Information

• Chemical Name: tert-butyl (2-((4-((4-fluorobenzyl)amino)-6-(prop-2-yn-1-ylamino)-1,3,5-triazin-2-yl)amino)ethyl)carbamate
• CAS No.: 1422258-59-0
• Molecular Formula: C₂₀H₂₆FN₇O₂
• Molecular Weight: 415.471

Synonyms:tert-butyl (2-((4-((4-fluorobenzyl)amino)-6-(prop-2-yn-1-ylamino)-1,3,5-triazin-2-yl)amino)ethyl)carbamate

Chemical Property of tert-butyl (2-((4-((4-fluorobenzyl)amino)-6-(prop-2-yn-1-ylamino)-1,3,5-triazin-2-yl)amino)ethyl)carbamate

Chemical Property:

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Technology Process of tert-butyl (2-((4-((4-fluorobenzyl)amino)-6-(prop-2-yn-1-ylamino)-1,3,5-triazin-2-yl)amino)ethyl)carbamate

There total 2 articles about tert-butyl (2-((4-((4-fluorobenzyl)amino)-6-(prop-2-yn-1-ylamino)-1,3,5-triazin-2-yl)amino)ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

tert-butyl (2-((4-chloro-6-(prop-2-yn-1-ylamino)-1,3,5-triazin-2-yl)amino)ethyl)carbamate (1422258-57-8) + para-fluorobenzylamine (140-75-0) → tert-butyl (2-((4-((4-fluorobenzyl)amino)-6-(prop-2-yn-1-ylamino)-1,3,5-triazin-2-yl)amino)ethyl)carbamate (1422258-59-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 120 ℃; for 3h;

DOI:10.1021/ja400427e

Reference yield:

N-( 4,6-dichloro-[1,3,5]triazin-2-yl )-N-prop-2-ynylamine (1206849-35-5) → tert-butyl (2-((4-((4-fluorobenzyl)amino)-6-(prop-2-yn-1-ylamino)-1,3,5-triazin-2-yl)amino)ethyl)carbamate (1422258-59-0)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 60 °C

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 120 °C

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

DOI:10.1021/ja400427e

Reference yield:

tert-butyl (2-((4-((4-fluorobenzyl)amino)-6-(prop-2-yn-1-ylamino)-1,3,5-triazin-2-yl)amino)ethyl)carbamate (1422258-59-0) → C15H18FN7 (1422258-71-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/ja400427e

upstream raw materials:

N-( 4,6-dichloro-[1,3,5]triazin-2-yl )-N-prop-2-ynylamine

tert-butyl (2-((4-chloro-6-(prop-2-yn-1-ylamino)-1,3,5-triazin-2-yl)amino)ethyl)carbamate

para-fluorobenzylamine

Downstream raw materials:

2-chloro-N-(2-((4-((4-fluorobenzyl)amino)-6-(prop-2-yn-1-ylamino)-1,3,5-triazin-2-yl)amino)ethyl)acetamide

C₁₅H₁₈FN₇

2-chloro-N-(2-((4-((4-fluorobenzyl)amino)-6-(prop-2-yn-1-ylamino)-1,3,5-triazin-2-yl)amino)ethyl)-5-nitrobenzamide

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