(R)-4-amino-6-(5-bromo-2-fluorophenyl)-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazine-2-carbonitrile

Base Information

Chemical Name:(R)-4-amino-6-(5-bromo-2-fluorophenyl)-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazine-2-carbonitrile
CAS No.:1397683-81-6
Molecular Formula:C₁₄H₁₁BrFN₅
Molecular Weight:348.177
Hs Code.:

Synonyms:(R)-4-amino-6-(5-bromo-2-fluorophenyl)-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazine-2-carbonitrile

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Chemical Property of (R)-4-amino-6-(5-bromo-2-fluorophenyl)-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazine-2-carbonitrile

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Technology Process of (R)-4-amino-6-(5-bromo-2-fluorophenyl)-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazine-2-carbonitrile

There total 2 articles about (R)-4-amino-6-(5-bromo-2-fluorophenyl)-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazine-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1397683-80-5
(R)-[1-(5-bromo-2-fluoro-phenyl)-2-(3,5-dicyano-pyrazol-1-yl)-1-methyl-ethyl]-carbamic acid tert-butyl ester

: 1397683-81-6
(R)-4-amino-6-(5-bromo-2-fluorophenyl)-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazine-2-carbonitrile

Guidance literature:: (R)-[1-(5-bromo-2-fluoro-phenyl)-2-(3,5-dicyano-pyrazol-1-yl)-1-methyl-ethyl]-carbamic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 20h;

With sodium carbonate; In dichloromethane;

Reference yield:

: 1398113-03-5
(4R)-4-(5-bromo-2-fluorophenyl)-4-methyl-1,2,3-oxathiazolidine-3-carboxylic acid 2,2-dioxide 1,1-dimethylethyl ester

: 1397683-81-6
(R)-4-amino-6-(5-bromo-2-fluorophenyl)-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazine-2-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 7 h / 80 °C / Inert atmosphere

2: formic acid / dichloromethane / 20 h / 40 °C / Inert atmosphere

With formic acid; potassium carbonate; In dichloromethane; acetonitrile;
DOI:10.1021/acsmedchemlett.1c00445

Reference yield: 65.0%

: 1397683-81-6
(R)-4-amino-6-(5-bromo-2-fluorophenyl)-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazine-2-carbonitrile

: 1397683-82-7
(R)-4-amino-6-(5-amino-2-fluorophenyl)-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazine-2-carbonitrile

Guidance literature:: (R)-4-amino-6-(5-bromo-2-fluorophenyl)-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazine-2-carbonitrile; With sodium azide; sodium carbonate; N,N`-dimethylethylenediamine; copper(l) iodide; In acetonitrile; at 110 - 120 ℃; for 6h;

With hydrogenchloride; In water; acetonitrile;