(S)-3-<(tert-Butyldimethylsilyl)oxy>-4-(tosyloxy)butanal diisopropyl acetal

Base Information

Chemical Name:(S)-3-<(tert-Butyldimethylsilyl)oxy>-4-(tosyloxy)butanal diisopropyl acetal
CAS No.:169522-71-8
Molecular Formula:C₂₃H₄₂O₆SSi
Molecular Weight:474.734
Hs Code.:

Synonyms:(S)-3-<(tert-Butyldimethylsilyl)oxy>-4-(tosyloxy)butanal diisopropyl acetal

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Chemical Property of (S)-3-<(tert-Butyldimethylsilyl)oxy>-4-(tosyloxy)butanal diisopropyl acetal

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Technology Process of (S)-3-<(tert-Butyldimethylsilyl)oxy>-4-(tosyloxy)butanal diisopropyl acetal

There total 3 articles about (S)-3-<(tert-Butyldimethylsilyl)oxy>-4-(tosyloxy)butanal diisopropyl acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 4447-60-3
Triisopropoxymethan

: 169522-70-7
(S)-3-<(tert-butyldimethylsilyl)oxy>-4-(tosyloxy)butanal

: 169522-71-8
(S)-3-<(tert-Butyldimethylsilyl)oxy>-4-(tosyloxy)butanal diisopropyl acetal

Guidance literature:: With toluene-4-sulfonic acid; In isopropyl alcohol; for 2h; Ambient temperature;
DOI:10.1021/jo00127a045

Reference yield:

: 130403-84-8
methyl (3S)-3-hydroxy-4-{[(4-methylphenyl)sulfonyl]oxy}butanoate

: 169522-71-8
(S)-3-<(tert-Butyldimethylsilyl)oxy>-4-(tosyloxy)butanal diisopropyl acetal

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / imidazole / dimethylformamide / 12 h / Ambient temperature

2: 78 percent / DIBAL / CH₂Cl₂; toluene / 0.5 h / -90 °C

3: 92 percent / p-TsOH / propan-2-ol / 2 h / Ambient temperature

With 1H-imidazole; diisobutylaluminium hydride; toluene-4-sulfonic acid; In dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; toluene;
DOI:10.1021/jo00127a045

Reference yield:

: 169522-69-4
Methyl (S)-3-<(tert-butyldimethylsilyl)oxy>-4-(tosyloxy)butanoate

: 169522-71-8
(S)-3-<(tert-Butyldimethylsilyl)oxy>-4-(tosyloxy)butanal diisopropyl acetal

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / DIBAL / CH₂Cl₂; toluene / 0.5 h / -90 °C

2: 92 percent / p-TsOH / propan-2-ol / 2 h / Ambient temperature

With diisobutylaluminium hydride; toluene-4-sulfonic acid; In dichloromethane; isopropyl alcohol; toluene;
DOI:10.1021/jo00127a045