(R)-[5-({2-[5-(4-cyanophenyl)-6-methoxycarbonyl-7-methyl-3-oxo-8-[3-(trifluoromethyl)phenyl]-5,8-dihydro-[1,2,4]triazolo[4,3-a]pyrimidin-2-yl]acetyl}methylamino)pentyl]trimethylammonium chloride

Base Information

Chemical Name:(R)-[5-({2-[5-(4-cyanophenyl)-6-methoxycarbonyl-7-methyl-3-oxo-8-[3-(trifluoromethyl)phenyl]-5,8-dihydro-[1,2,4]triazolo[4,3-a]pyrimidin-2-yl]acetyl}methylamino)pentyl]trimethylammonium chloride
CAS No.:1426800-79-4
Molecular Formula:C₃₃H₃₉F₃N₇O₄*Cl
Molecular Weight:690.165
Hs Code.:

(R)-[5-({2-[5-(4-cyanophenyl)-6-methoxycarbonyl-7-methyl-3-oxo-8-[3-(trifluoromethyl)phenyl]-5,8-dihydro-[1,2,4]triazolo[4,3-a]pyrimidin-2-yl]acetyl}methylamino)pentyl]trimethylammonium chloride

Synonyms:(R)-[5-({2-[5-(4-cyanophenyl)-6-methoxycarbonyl-7-methyl-3-oxo-8-[3-(trifluoromethyl)phenyl]-5,8-dihydro-[1,2,4]triazolo[4,3-a]pyrimidin-2-yl]acetyl}methylamino)pentyl]trimethylammonium chloride

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Chemical Property of (R)-[5-({2-[5-(4-cyanophenyl)-6-methoxycarbonyl-7-methyl-3-oxo-8-[3-(trifluoromethyl)phenyl]-5,8-dihydro-[1,2,4]triazolo[4,3-a]pyrimidin-2-yl]acetyl}methylamino)pentyl]trimethylammonium chloride

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Technology Process of (R)-[5-({2-[5-(4-cyanophenyl)-6-methoxycarbonyl-7-methyl-3-oxo-8-[3-(trifluoromethyl)phenyl]-5,8-dihydro-[1,2,4]triazolo[4,3-a]pyrimidin-2-yl]acetyl}methylamino)pentyl]trimethylammonium chloride

There total 11 articles about (R)-[5-({2-[5-(4-cyanophenyl)-6-methoxycarbonyl-7-methyl-3-oxo-8-[3-(trifluoromethyl)phenyl]-5,8-dihydro-[1,2,4]triazolo[4,3-a]pyrimidin-2-yl]acetyl}methylamino)pentyl]trimethylammonium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1426800-78-3
(R)-5-(4-cyano-phenyl)-2-{[(5-dimethylamino-pentyl)-methyl-carbamoyl]-methyl}-7-methyl-3-oxo-8-(3-trifluoromethyl-phenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylic acid methyl ester

: 1426800-79-4
(R)-[5-({2-[5-(4-cyanophenyl)-6-methoxycarbonyl-7-methyl-3-oxo-8-[3-(trifluoromethyl)phenyl]-5,8-dihydro-[1,2,4]triazolo[4,3-a]pyrimidin-2-yl]acetyl}methylamino)pentyl]trimethylammonium chloride

Guidance literature:: With potassium carbonate; In acetonitrile; at 20 ℃; for 24h;

Reference yield:

: 1426800-21-6
4-(4-cyanophenyl)-2-(N'-ethoxycarbonylhydrazino)-6-methyl-1-[3-(trifluoromethyl)phenyl]-1,4-dihydropyrimidine-5-carboxylic acid methyl ester

: 1426800-79-4
(R)-[5-({2-[5-(4-cyanophenyl)-6-methoxycarbonyl-7-methyl-3-oxo-8-[3-(trifluoromethyl)phenyl]-5,8-dihydro-[1,2,4]triazolo[4,3-a]pyrimidin-2-yl]acetyl}methylamino)pentyl]trimethylammonium chloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: ethanol / 1 h / 150 °C / Microwave irradiation

2.1: Daicel Chiralpak IC column / dichloromethane; isopropyl alcohol / Resolution of racemate

3.1: caesium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

4.1: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.67 h / 20 °C

5.2: 18 h

6.1: potassium carbonate / acetonitrile / 24 h / 20 °C

With water; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;

Reference yield:

: 674290-07-4
4-(4-cyanophenyl)-6-methyl-2-thioxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid methyl ester

: 1426800-79-4
(R)-[5-({2-[5-(4-cyanophenyl)-6-methoxycarbonyl-7-methyl-3-oxo-8-[3-(trifluoromethyl)phenyl]-5,8-dihydro-[1,2,4]triazolo[4,3-a]pyrimidin-2-yl]acetyl}methylamino)pentyl]trimethylammonium chloride

Guidance literature:: Multi-step reaction with 8 steps

1.1: urea hydrogen peroxide adduct / ethanol / 5 h / 20 °C

1.2: 16 h / 20 °C

2.1: triethylamine / tetrahydrofuran / 1 h / 0 °C

3.1: ethanol / 1 h / 150 °C / Microwave irradiation

4.1: Daicel Chiralpak IC column / dichloromethane; isopropyl alcohol / Resolution of racemate

5.1: caesium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

6.1: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.67 h / 20 °C

7.2: 18 h

8.1: potassium carbonate / acetonitrile / 24 h / 20 °C

With water; urea hydrogen peroxide adduct; potassium carbonate; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;