4a-hydroxy-8-[hydroxy-(4-methoxy-phenyl)-methyl]-4-(4-methoxy-phenyl)-3,4,4a,5,6,7-hexahydro-1H-quinazoline-2-thione

Base Information

• Chemical Name: 4a-hydroxy-8-[hydroxy-(4-methoxy-phenyl)-methyl]-4-(4-methoxy-phenyl)-3,4,4a,5,6,7-hexahydro-1H-quinazoline-2-thione
• CAS No.: 888724-12-7
• Molecular Formula: C₂₃H₂₆N₂O₄S
• Molecular Weight: 426.536

Synonyms:4a-hydroxy-8-[hydroxy-(4-methoxy-phenyl)-methyl]-4-(4-methoxy-phenyl)-3,4,4a,5,6,7-hexahydro-1H-quinazoline-2-thione

Chemical Property of 4a-hydroxy-8-[hydroxy-(4-methoxy-phenyl)-methyl]-4-(4-methoxy-phenyl)-3,4,4a,5,6,7-hexahydro-1H-quinazoline-2-thione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4a-hydroxy-8-[hydroxy-(4-methoxy-phenyl)-methyl]-4-(4-methoxy-phenyl)-3,4,4a,5,6,7-hexahydro-1H-quinazoline-2-thione

There total 2 articles about 4a-hydroxy-8-[hydroxy-(4-methoxy-phenyl)-methyl]-4-(4-methoxy-phenyl)-3,4,4a,5,6,7-hexahydro-1H-quinazoline-2-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2,6-bis-(4-methoxyphenyl)-1,6-dioxadispiro[2.1.2.3]decan-4-one (888724-07-0) + thiourea (17356-08-0) → 4a-hydroxy-8-[hydroxy-(4-methoxy-phenyl)-methyl]-4-(4-methoxy-phenyl)-3,4,4a,5,6,7-hexahydro-1H-quinazoline-2-thione (888724-12-7)

Guidance literature:

With potassium hydroxide; In ethanol; for 3h; Heating;

DOI:10.1002/ardp.200500982

Reference yield:

(2E,6E)-2,6-bis(4-methoxybenzylidene)cyclohexanone (6275-32-7,62085-71-6) → 4a-hydroxy-8-[hydroxy-(4-methoxy-phenyl)-methyl]-4-(4-methoxy-phenyl)-3,4,4a,5,6,7-hexahydro-1H-quinazoline-2-thione (888724-12-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / aq. NaOH; aq. H₂O₂ / acetone; dioxane / 8 h / 20 °C

2: 65 percent / KOH / ethanol / 3 h / Heating

With potassium hydroxide; sodium hydroxide; dihydrogen peroxide; In 1,4-dioxane; ethanol; acetone;

DOI:10.1002/ardp.200500982

Reference yield: 65.0%

4a-hydroxy-8-[hydroxy-(4-methoxy-phenyl)-methyl]-4-(4-methoxy-phenyl)-3,4,4a,5,6,7-hexahydro-1H-quinazoline-2-thione (888724-12-7) + 4-nitrobenzaldehdye (555-16-8) + chloroacetic acid (79-11-8) → 5a-Hydroxy-9-[hydroxy-(4-methoxy-phenyl)-methyl]-5-(4-methoxy-phenyl)-2-[1-(4-nitro-phenyl)-meth-(E)-ylidene]-5a,6,7,8-tetrahydro-5H-thiazolo[2,3-b]quinazolin-3-one

Guidance literature:

With sodium acetate; In acetic anhydride; acetic acid; for 3h; Heating;

DOI:10.1002/ardp.200500982

upstream raw materials:

2,6-bis-(4-methoxyphenyl)-1,6-dioxadispiro[2.1.2.3]decan-4-one

thiourea

(2E,6E)-2,6-bis(4-methoxybenzylidene)cyclohexanone

Downstream raw materials:

5a-hydroxy-9-[hydroxy-(4-methoxy-phenyl)-methyl]-5-(4-methoxy-phenyl)-5a,6,7,8-tetrahydro-5H-thiazolo[2,3-b]quinazolin-3-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 888724-12-7 4a-hydroxy-8-[hydroxy-(4-methoxy-phenyl)-methyl]-4-(4-methoxy-phenyl)-3,4,4a,5,6,7-hexahydro-1H-quinazoline-2-thione

Send

Send

Metric Ton KG G Pound L ML

Send

Send