Chemical Property of Teichomycin
Chemical Property:
- Appearance/Colour:White powder
- Melting Point:310 °C (decomp)
- Refractive Index:1.76
- PSA：662.41000
- Density:1.69g/cm3
- LogP:4.61850
- Storage Temp.:2-8°C
- Solubility.:H2O: soluble10mg/mL
- Water Solubility.:Sparingly soluble in water
- XLogP3:0.5
- Hydrogen Bond Donor Count:24
- Hydrogen Bond Acceptor Count:34
- Rotatable Bond Count:20
- Exact Mass:1877.5565820
- Heavy Atom Count:132
- Complexity:3920
- Purity/Quality:
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99% *data from raw suppliers
Teicoplanin *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CCCCCCCCCC(=O)NC1C(C(C(OC1OC2=C3C=C4C=C2OC5=C(C=C(C=C5)C(C6C(=O)NC(C7=C(C(=CC(=C7)O)OC8C(C(C(C(O8)CO)O)O)O)C9=C(C=CC(=C9)C(C(=O)N6)NC(=O)C4NC(=O)C1C2=CC(=CC(=C2)OC2=C(C=CC(=C2)C(C(=O)NC(CC2=CC(=C(O3)C=C2)Cl)C(=O)N1)N)O)O)O)C(=O)O)OC1C(C(C(C(O1)CO)O)O)NC(=O)C)Cl)CO)O)O
- Isomeric SMILES:CCCCCCCCCC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1OC2=C3C=C4C=C2OC5=C(C=C(C=C5)[C@H]([C@H]6C(=O)N[C@H](C7=C(C(=CC(=C7)O)O[C@@H]8[C@H]([C@H]([C@@H]([C@H](O8)CO)O)O)O)C9=C(C=CC(=C9)[C@H](C(=O)N6)NC(=O)[C@@H]4NC(=O)[C@@H]1C2=CC(=CC(=C2)OC2=C(C=CC(=C2)[C@@H](C(=O)N[C@H](CC2=CC(=C(O3)C=C2)Cl)C(=O)N1)N)O)O)O)C(=O)O)O[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)NC(=O)C)Cl)CO)O)O
- Recent EU Clinical Trials:Liverpool Pharmacokinetic/pharmacodynamics study of teicoplanin in children (LIPSTIC).
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Description
Teicoplanin is a new antibiotic, the second glycopeptide to be developed in over 30 years.
Compared with vancomycin, the only such agent currently available, teicoplanin is
equiefficacious, and has milder side-effects and a longer half-life, allowing once-daily
dosing and bolus injection. Teicoplanin is claimed to have an overall cure rate of 92% in
infections involving skin, joint and bone, endocaditis and septicemia.
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Uses
anticonvulsant, antipsychotic Teicoplanin complex is family of closely related metabolites produced by Actinoplanes teichomyceticus. Teicoplanin complex possesses potent broad spectrum antibiotic activity against Gram positive bacteria, including MRSA and E. faecalis. The metabolites share a common glycopeptide core (teicoplanin A-3) on which a family of fatty acids varying in length, degree of saturation and branching are linked as amides through one of the aminoglycoside moieties. The major component of the complex is teicoplanin A2 which itself has five major components (teicoplanin A2-1 to A2-5) and four minor components (teicoplanin RS-1 to RS-4). antidepressant
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Clinical Use
Antibacterial agent.
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Drug interactions
Potentially hazardous interactions with other drugs
None known
