Technology Process of 5-(2,4-difluorobenzyl)-1-(2-fluorobenzyl)-3-iodopyridin-2(1H)-one
There total 5 articles about 5-(2,4-difluorobenzyl)-1-(2-fluorobenzyl)-3-iodopyridin-2(1H)-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-(2,4-difluorobenzyl)-3-iodopyridin-2(1H)-one;
With
sodium hydride;
In
N,N-dimethyl-formamide; mineral oil;
for 0.25h;
o-fluorobenzyl bromide;
In
N,N-dimethyl-formamide; mineral oil;
at 20 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium iodide; triethylsilane / acetonitrile / 20 °C
1.2: 30 °C
2.1: trifluoroacetic acid; acetic acid; N-iodo-succinimide / 20 °C
2.2: Cooling with ice
3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h
3.2: 2 h / 20 °C
With
triethylsilane; N-iodo-succinimide; sodium hydride; acetic acid; trifluoroacetic acid; sodium iodide;
In
N,N-dimethyl-formamide; acetonitrile; mineral oil;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-butyllithium / cyclohexane; tert-butyl methyl ether / 1.25 h / -32 °C / Inert atmosphere
1.2: -32 - 0 °C / Inert atmosphere
2.1: sodium iodide; triethylsilane / acetonitrile / 20 °C
2.2: 30 °C
3.1: trifluoroacetic acid; acetic acid; N-iodo-succinimide / 20 °C
3.2: Cooling with ice
4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h
4.2: 2 h / 20 °C
With
triethylsilane; N-iodo-succinimide; n-butyllithium; sodium hydride; acetic acid; trifluoroacetic acid; sodium iodide;
In
tert-butyl methyl ether; cyclohexane; N,N-dimethyl-formamide; acetonitrile; mineral oil;
