N-(4-(7,8-dimethoxy-3-(2-nitrophenylsulfonyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-yl)phenyl)-2-nitrobenzenesulfonamide

Base Information

Chemical Name:N-(4-(7,8-dimethoxy-3-(2-nitrophenylsulfonyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-yl)phenyl)-2-nitrobenzenesulfonamide
CAS No.:1440966-03-9
Molecular Formula:C₃₀H₂₈N₄O₁₀S₂
Molecular Weight:668.705
Hs Code.:

Synonyms:N-(4-(7,8-dimethoxy-3-(2-nitrophenylsulfonyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-yl)phenyl)-2-nitrobenzenesulfonamide

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Chemical Property of N-(4-(7,8-dimethoxy-3-(2-nitrophenylsulfonyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-yl)phenyl)-2-nitrobenzenesulfonamide

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Technology Process of N-(4-(7,8-dimethoxy-3-(2-nitrophenylsulfonyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-yl)phenyl)-2-nitrobenzenesulfonamide

There total 6 articles about N-(4-(7,8-dimethoxy-3-(2-nitrophenylsulfonyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-yl)phenyl)-2-nitrobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1440966-02-8
4-(7,8-dimethoxy-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-yl)aniline

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 1440966-03-9
N-(4-(7,8-dimethoxy-3-(2-nitrophenylsulfonyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-yl)phenyl)-2-nitrobenzenesulfonamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1038/aps.2012.151

Reference yield:

: 99-81-0
4-Nitrophenacyl bromide

: 1440966-03-9
N-(4-(7,8-dimethoxy-3-(2-nitrophenylsulfonyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-yl)phenyl)-2-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide; sodium tetrahydroborate / tetrahydrofuran; methanol / 0.58 h / 0 - 20 °C

2: tetrahydrofuran / 20 °C / Inert atmosphere; Reflux

3: PPA / 1.5 h / 100 °C

4: iron; hydrogenchloride / ethanol; water / 1 h / Reflux

5: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; sodium tetrahydroborate; iron; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;
DOI:10.1038/aps.2012.151

Reference yield:

: 136247-26-2
α-<2-amino>ethyl>-p-nitrobenzyl alcohol

: 1440966-03-9
N-(4-(7,8-dimethoxy-3-(2-nitrophenylsulfonyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-yl)phenyl)-2-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: PPA / 1.5 h / 100 °C

2: iron; hydrogenchloride / ethanol; water / 1 h / Reflux

3: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; iron; triethylamine; In ethanol; dichloromethane; water;
DOI:10.1038/aps.2012.151