Technology Process of compound S
There total 6 articles about compound S which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
benzyl (S)-Lactate;
With
2,6-dimethylpyridine;
In
dichloromethane;
at -78 ℃;
for 0.166667h;
With
trifluoromethylsulfonic anhydride;
In
dichloromethane;
at -78 - -50 ℃;
for 0.5h;
methyl 2-Phenylacetylamino-4-Aminooxybutyrate;
With
2,6-dimethylpyridine;
In
dichloromethane;
at 20 ℃;
for 18h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium hydroxide / methanol / 24 h / 20 °C
2.1: triethylamine / N,N-dimethyl-formamide
3.1: triethylamine / dichloromethane / 1 h / 0 °C
4.1: triethylamine / acetonitrile / 24 h / 20 °C
5.1: methylhydrazine / dichloromethane / 3 h
6.1: 2,6-dimethylpyridine; trifluoromethanesulfonic acid anhydride / dichloromethane / 0.5 h / -78 - -50 °C
6.2: 2,6-lutidine / 15 / 18 h / 20 °C
With
2,6-dimethylpyridine; potassium hydroxide; trifluoromethanesulfonic acid anhydride; triethylamine; methylhydrazine;
In
methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1139/v03-122
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triethylamine / dichloromethane / 1 h / 0 °C
2.1: triethylamine / acetonitrile / 24 h / 20 °C
3.1: methylhydrazine / dichloromethane / 3 h
4.1: 2,6-dimethylpyridine; trifluoromethanesulfonic acid anhydride / dichloromethane / 0.5 h / -78 - -50 °C
4.2: 2,6-lutidine / 15 / 18 h / 20 °C
With
2,6-dimethylpyridine; trifluoromethanesulfonic acid anhydride; triethylamine; methylhydrazine;
In
dichloromethane; acetonitrile;
DOI:10.1139/v03-122
